Phase II trial of irofulven (6-hydroxymethylacylfulvene) for patients with advanced renal cell carcinoma Journal Article
| Authors: | Berg, W. J.; Schwartz, L.; Yu, R.; Mazumdar, M.; Motzer, R. J. |
| Article Title: | Phase II trial of irofulven (6-hydroxymethylacylfulvene) for patients with advanced renal cell carcinoma |
| Abstract: | The aim of this study was to determine the antitumor activity of irofulven (6-hydroxymethylacylfulvene) in patients with advanced renal cell carcinoma (RCC). Eligible patients had advanced renal cell carcinoma with bidimensionally measurable disease, a Karnofsky performance status of at least 70, life expectancy of greater than three months, no prior treatment with chemotherapy, and no evidence of brain metastases. Irofulven was administered at a dose of 11 mg/m2 by 5-min intravenous infusion, on 5 consecutive days. Cycles were repeated every 28 days. Thirteen patients were enrolled in this study and 12 were evaluable for response. Of the twelve evaluable patients, no major responses were achieved. Eight patients had stable disease as best response, Toxicity included myelosuppression and gastrointestinal side effects. At the dose and schedule used in this trial, irofulven did not produce clinical response in RCC. |
| Keywords: | adult; clinical article; treatment outcome; aged; middle aged; unclassified drug; clinical trial; advanced cancer; antineoplastic agents; antineoplastic agent; phase 2 clinical trial; bone marrow suppression; gastrointestinal symptom; antineoplastic activity; kidney carcinoma; kidney neoplasms; carcinoma, renal cell; infusions, intravenous; life expectancy; sesquiterpenes; phase ii trial; 6 hydroxymethylacylfulvene; humans; prognosis; human; male; female; priority journal; article; advanced renal cell carcinoma; irofulven |
| Journal Title: | Investigational New Drugs |
| Volume: | 19 |
| Issue: | 4 |
| ISSN: | 0167-6997 |
| Publisher: | Springer |
| Date Published: | 2001-11-01 |
| Start Page: | 317 |
| End Page: | 320 |
| Language: | English |
| DOI: | 10.1023/a:1010609810517 |
| PUBMED: | 11561691 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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