Mzf1 controls cell proliferation and tumorigenesis Journal Article

   


Authors: Gaboli, M.; Kotsi, P. A.; Gurrieri, C.; Cattoretti, G.; Ronchetti, S.; Cordon-Cardo, C.; Broxmeyer, H. E.; Hromas, R.; Pandolfi, P. P.
Article Title: Mzf1 controls cell proliferation and tumorigenesis
Abstract: MZF1 is a transcription factor belonging to the Krüppel family of zinc finger proteins, expressed in totipotent hemopoietic cells as well as in myeloid progenitors. Here we have inactivated Mzfi1 by gene targeting. Mzf1-/- mice develop lethal neoplasias characterized by the infiltration and complete disruption of the liver architecture by a monomorphic population of cells of myeloid origin reminiscent of human chloromas. Mzf1 inactivation results in a striking increase of the autonomous cell proliferation and of the ability of Mzf1-/- hemopoietic progenitors to sustain long-term hemopoiesis. These findings demonstrate that Mzf1 can act as a tumor/ growth suppressor in the hemopoietic compartment.
Keywords: unclassified drug; dna-binding proteins; nonhuman; neoplasm; cell proliferation; animal cell; mouse; animals; mice; mice, knockout; bone marrow cells; cells, cultured; gene targeting; cell division; transcription factor; time factors; carcinogenesis; transcription factors; stem cell; tumorigenesis; cell transformation, neoplastic; cancer inhibition; hematopoietic cell; hematopoietic stem cells; hematopoiesis; gene inactivation; protein family; zinc finger protein; genes, tumor suppressor; knockout mouse; promyelocyte; zinc fingers; knockout mice; priority journal; article; myeloid progenitors; mzf; protein mzf1
Journal Title: Genes and Development
Volume: 15
Issue: 13
ISSN: 0890-9369
Publisher: Cold Spring Harbor Laboratory Press  
Date Published: 2001-07-01
Start Page: 1625
End Page: 1630
Language: English
DOI: 10.1101/gad.902301
PUBMED: 11445537
PROVIDER: scopus
PMCID: PMC312729
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0035395824&partnerID=40&md5=ea8a8e252feda8aed7de796e210dc9d0
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Carmela Gurrieri
    11 Gurrieri
  2. Mirella P Gaboli
    19 Gaboli
  3. Paraskevi A Kotsi
    6 Kotsi
  4. Simona Ronchetta
    10 Ronchetta
  5. Pier Paolo Pandolfi Derinaldis
    353 Pandolfi Derinaldis
  6. Carlos Cordon-Cardo
    612 Cordon-Cardo
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