FDG-PET standardized uptake values in normal anatomical structures using iterative reconstruction segmented attenuation correction and filtered back-projection Journal Article

  

Authors:	Ramos, C. D.; Erdi, Y. E.; Gonen, M.; Riedel, E.; Yeung, H. W. D.; Macapinlac, H. A.; Chisin, R.; Larson, S. M.
Article Title:	FDG-PET standardized uptake values in normal anatomical structures using iterative reconstruction segmented attenuation correction and filtered back-projection
Abstract:	Filtered back-projection (FBP) is the most commonly used reconstruction method for PET images, which are usually noisy. The iterative reconstruction segmented attenuation correction (IRSAC) algorithm improves image quality without reducing image resolution. The standardized uptake value (SUV) is the most clinically utilized quantitative parameter of [fluorine-18]fluoro-2-deoxy-D-glucose (FDG) accumulation. The objective of this study was to obtain a table of SUVs for several normal anatomical structures from both routinely used FBP and IRSAC reconstructed images and to compare the data obtained with both methods. Twenty whole-body PET scans performed in consecutive patients with proven or suspected non-small cell lung cancer were retrospectively analyzed. Images were processed using both IRSAC and FBP algorithms. Non-quantitative or gaussian filters were used to smooth the transmission scan when using FBP or IRSAC algorithms, respectively. A phantom study was performed to evaluate the effect of different filters on SUV. Maximum and average SUVs and (SUVmax SUVavg) were calculated in 28 normal anatomical structures and in one pathological site. The phantom study showed that the use of a nonquantitative smoothing filter in the transmission scan results in a less accurate quantification and in a 20% underestimation of the actual measurement. Most anatomical structures were identified in all patients using the IRSAC images. On average, and SUVavg SUVmax measured on IRSAC images using a gaussian filter in the transmission scan were respectively 20% and 8% higher than the SUVs calculated from conventional FBP images. Scatterplots of the data values showed an overall strong relationship between IRSAC and FBP SUVs. Individual scatterplots of each site demonstrated a weaker relationship for lower SUVs and for SUVmax than for higher SUVs and SUVavg. A set of reference values was obtained for SUVmax and SUVavg of normal anatomical structures, calculated with both IRSAC and FBP image reconstruction algorithms. The use of IRSAC and a gaussian filter for the transmission scan seems to give more accurate SUVs than are obtained from conventional FBP images using a nonquantitative filter for the transmission scan.
Keywords:	adult; clinical article; aged; positron emission tomography; radiopharmaceuticals; lung non small cell cancer; algorithms; standardization; whole body radiation; image quality; reference values; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; intermethod comparison; phantom; image processing, computer-assisted; models, anatomic; fluorodeoxyglucose; image reconstruction; tomography, emission-computed; filter; standardized uptake value; iterative reconstruction; humans; human; male; female; article; normal structures
Journal Title:	European Journal of Nuclear Medicine
Volume:	28
Issue:	2
ISSN:	0340-6997
Publisher:	Springer Verlag
Date Published:	2001-02-01
Start Page:	155
End Page:	164
Language:	English
DOI:	10.1007/s002590000421
PUBMED:	11303885
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0035114719&partnerID=40&md5=990dd0490d4bd44fcc03aa33ffe37a6f
Notes:	Export Date: 21 May 2015 -- Source: Scopus

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