Helicobacter pylori decreases gastric mucosal glutathione Journal Article
| Authors: | Shirin, H.; Pinto, J. T.; Liu, L. U.; Merzianu, M.; Sordillo, E. M.; Moss, S. F. |
| Article Title: | Helicobacter pylori decreases gastric mucosal glutathione |
| Abstract: | Activation of oxidative stress pathways may contribute to gastric epithelial damage and mutagenesis caused by Helicobacter pylori. We measured the effect of H. pylori on the concentrations of reduced glutathione (GSH), an important endogenous defense against oxidant damage, in gastric epithelial cells in vivo and in vitro. GSH concentrations were significantly lower in gastric biopsies from 19 H. pylori-infected patients than 38 normal controls, and correlated inversely with inflammatory cell numbers. In vitro, H. pylori initially increased GSH levels in AGS cells, but subsequently depleted intracellular GSH stores completely after 24 h. No GSH was detected in H. pylori. Our data suggest that diminished GSH levels with H. pylori colonization of the gastric mucosa may be due to a direct effect of the bacterium as well as through the associated inflammatory response. © 2001 Elsevier Science Ireland Ltd. |
| Keywords: | adolescent; adult; controlled study; human tissue; aged; aged, 80 and over; middle aged; major clinical study; nonhuman; cell line; inflammation; bacteria (microorganisms); biopsy; carcinogenesis; epithelial cells; cellular distribution; neutrophils; oxidative stress; monocytes; bacterial colonization; stomach carcinoma; mutagenesis; helicobacter pylori; glutathione; coculture techniques; gastritis; gastric mucosa; stomach biopsy; stomach mucosa; stomach epithelium; humans; human; male; female; priority journal; article |
| Journal Title: | Cancer Letters |
| Volume: | 164 |
| Issue: | 2 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2001-03-26 |
| Start Page: | 127 |
| End Page: | 133 |
| Language: | English |
| DOI: | 10.1016/s0304-3835(01)00383-4 |
| PUBMED: | 11179826 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
