Clinicopathologic analysis of patients with adult rhabdomyosarcoma Journal Article

Authors: Hawkins, W. G.; Hoos, A.; Antonescu, C. R.; Urist, M. J.; Leung, D. H. Y.; Gold, J. S.; Woodruff, J. M.; Lewis, J. J.; Brennan, M. F.
Article Title: Clinicopathologic analysis of patients with adult rhabdomyosarcoma
Abstract: BACKGROUND. Rhabdomyosarcoma (RMS) in adults (age ≥ 16 years) is rare, accounting for less than 3% of adult soft tissue sarcomas. There is little information describing the disease biology or clinicopathologic factors that influence survival in adults with RMS. The objective of this study was to define the factors in patients with adult RMS that predict outcome, disease progression, and survival. METHODS. Eighty-four adult patients with a pathologic diagnosis of RMS that was confirmed by immunohistochemistry were identified by a prospective inpatient data base during the period 1982-1999 and were analyzed for disease specific survival and metastasis free survival using the Kaplan-Meier actuarial method. Statistical significance was evaluated using the log-rank test for univariate influence and a Cox regression model for multivariate influence. RESULTS. The median disease specific survival was 22 months. Patient age, extent of disease, tumor size at the time of diagnosis, and margin status after resection were significant predictors of disease specific survival. Patients who underwent a complete resection had a significantly longer median survival (105 months) compared with any other subgroup of patients. The histologic subtype did not predict patient survival but did vary with patient age. Most notably, the proportion of the pleomorphic subtype increased with advancing age, accounting for 42% of RMS in patients over the age of 40 years. CONCLUSIONS. The most important predictors of outcome in patients with adult RMS are patient age, tumor size, extent of disease, and margin status after resection. In contrast to patients with pediatric RMS, no association was noted between survival and histologic subtype in this group of patients with adult RMS. All histologic subtypes of RMS are aggressive malignancies with poor disease specific survival despite aggressive multimodality management. © 2001 American Cancer Society.
Keywords: immunohistochemistry; survival; adolescent; adult; aged; middle aged; survival analysis; cancer surgery; major clinical study; clinical trial; histopathology; cancer recurrence; combined modality therapy; cancer incidence; metastasis; proportional hazards models; age; sarcoma; survival time; cancer size; neoplasm metastasis; soft tissue sarcoma; rhabdomyosarcoma; adulthood; clinicopathologic; humans; prognosis; human; male; female; priority journal; article
Journal Title: Cancer
Volume: 91
Issue: 4
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2001-02-15
Start Page: 794
End Page: 803
Language: English
DOI: 10.1002/1097-0142(20010215)91:4<794::aid-cncr1066>;2-q
PUBMED: 11241248
PROVIDER: scopus
Notes: Presented in part at the 53rd Annual Meeting of the Society of Surgical Oncology; 2000 Mar 16-19; New Orleans, LA -- Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    782 Brennan
  2. Jonathan J Lewis
    107 Lewis
  3. Denis Heng Yan Leung
    114 Leung
  4. William G Hawkins
    18 Hawkins
  5. Axel Hoos
    28 Hoos
  6. Jason Gold
    22 Gold
  7. Cristina R Antonescu
    612 Antonescu
  8. James M Woodruff
    138 Woodruff
  9. Marshall   Urist
    9 Urist