Development of spontaneous factor VIII inhibitor in association with acute graft-versus-host disease Journal Article


Authors: Brentjens, R. J.; Smith, L.; Reich, L.; Jakubowski, A. A.
Article Title: Development of spontaneous factor VIII inhibitor in association with acute graft-versus-host disease
Abstract: A 57-year-old female with recurrent AML underwent a T cell-depleted (TCD) bone marrow (BM) plus TCD and CD34-selected peripheral blood stem cell (PBSC) transplant. Eleven weeks post transplantation, the patient developed acute graft-versus-host disease (GVHD) manifested by rash and elevated liver enzymes. Concurrently, the patient presented with a bleeding diathesis and a left forearm hematoma due to the development of a spontaneous factor VIII inhibitor. She was treated with human recombinant factor VIII and intravenous methylprednisolone. Subsequently she was managed with a prednisone taper leading to resolution of the GVHD, as well as the spontaneous factor VIII inhibitor. Bone marrow transplant-related spontaneous factor VIII inhibitor has previously been reported in association with one patient with chronic GVHD. To our knowledge this is the first report of spontaneous factor VIII inhibitor associated with acute GVHD.
Keywords: adult; controlled study; middle aged; antibiotic agent; transplantation, homologous; prednisone; clinical feature; cancer recurrence; case report; cytarabine; t lymphocyte; cd34 antigen; etoposide; cyclophosphamide; steroid; hematopoietic stem cell transplantation; thiotepa; febrile neutropenia; rash; chronic disease; whole body radiation; peripheral blood stem cell; leukemia, myeloid; recombinant proteins; mitoxantrone; comorbidity; acute myeloblastic leukemia; graft versus host reaction; methylprednisolone; idarubicin; liver enzyme; bone marrow transplantation; graft vs host disease; hematoma; ganciclovir; cytomegalovirus; lymphocyte depletion; acute disease; thymocyte antibody; blood clotting factor 8; factor viii; bleeding tendency; forearm; viremia; graft-versus-host disease; blood clotting factor 8 antibody; humans; human; female; priority journal; article; isoantibodies; peripheral blood stem cell transplant; spontaneous factor viii inhibitor; recombinant blood clotting factor 8
Journal Title: Bone Marrow Transplantation
Volume: 27
Issue: 8
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2001-04-01
Start Page: 887
End Page: 889
Language: English
DOI: 10.1038/sj.bmt.1703009
PUBMED: 11477449
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Larry J Smith
    7 Smith
  2. Renier J Brentjens
    214 Brentjens
  3. Lilian M Reich
    84 Reich