The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation Journal Article

   


Authors: Xu, K.; Olsen, O.; Tzvetkova Robev, D.; Tessier-Lavigne, M.; Nikolov, D. B.
Article Title: The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation
Abstract: The amyloid precursor protein (APP) has garnered considerable attention due to its genetic links to Alzheimer’s disease. Death receptor 6 (DR6) was recently shown to bind APP via the protein extracellular regions, stimulate axonal pruning, and inhibit synapse formation. Here, we report the crystal structure of the DR6 ectodomain in complex with the E2 domain of APP and show that it supports a model for APP-induced dimerization and activation of cell surface DR6. © 2015 Xu et al.
Keywords: crystal structure; dimerization; amyloid precursor protein; death receptor 6; signal activation
Journal Title: Genes and Development
Volume: 29
Issue: 8
ISSN: 0890-9369
Publisher: Cold Spring Harbor Laboratory Press  
Date Published: 2015-04-15
Start Page: 785
End Page: 790
Language: English
DOI: 10.1101/gad.257675.114
PROVIDER: scopus
PMCID: PMC4403255
PUBMED: 25838500
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84927701193&partnerID=40&md5=9d8ffc18a52dd1015f9ec67389f2a081
Notes: Export Date: 4 May 2015 -- Source: Scopus
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MSK Authors
  1. Dimitar B Nikolov
    86 Nikolov
  2. Kai Xu
    21 Xu
  3. Dorothea Dimitrova Robev
    16 Robev
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