Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1 Journal Article
| Authors: | dos Santos, L. I.; Galvão-Filho, B.; de Faria, P. C.; Junqueira, C.; Dutra, M. S.; Teixeira, S. M. R.; Rodrigues, M. M.; Ritter, G.; Bannard, O.; Fearon, D. T.; Antonelli, L. R.; Gazzinelli, R. T. |
| Article Title: | Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1 |
| Abstract: | The development of cancer immunotherapy has long been a challenge. Here, we report that prophylactic vaccination with a highly attenuated Trypanosoma cruzi strain expressing NY-ESO-1 (CL-14-NY-ESO-1) induces both effector memory and effector CD8+ T lymphocytes that efficiently prevent tumor development. However, the therapeutic effect of such a vaccine is limited. We also demonstrate that blockade of Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) during vaccination enhances the frequency of NY-ESO-1-specific effector CD8+ T cells producing IFN-γ and promotes lymphocyte migration to the tumor infiltrate. As a result, therapy with CL-14-NY-ESO-1 together with anti-CTLA-4 is highly effective in controlling the development of an established melanoma. © 2014, Springer-Verlag Berlin Heidelberg. |
| Keywords: | immunotherapy; trypanosoma cruzi; ny-eso-1; anti-ctla-4; cancer |
| Journal Title: | Cancer Immunology, Immunotherapy |
| Volume: | 64 |
| Issue: | 3 |
| ISSN: | 0340-7004 |
| Publisher: | Springer |
| Date Published: | 2015-03-01 |
| Start Page: | 311 |
| End Page: | 323 |
| Language: | English |
| DOI: | 10.1007/s00262-014-1634-8 |
| PROVIDER: | scopus |
| PUBMED: | 25403749 |
| DOI/URL: | |
| Notes: | Export Date: 4 May 2015 -- Source: Scopus |
