Evolutionary theory of cancer Journal Article
| Authors: | Attolini, C. S. O.; Michor, F. |
| Article Title: | Evolutionary theory of cancer |
| Abstract: | As Theodosius Dobzhansky famously noted in 1973, "Nothing in biology makes sense except in the light of evolution," and cancer is no exception to this rule. Our understanding of cancer initiation, progression, treatment, and resistance has advanced considerably by regarding cancer as the product of evolutionary processes. Here we review the literature of mathematical models of cancer evolution and provide a synthesis and discussion of the field. © 2009 New York Academy of Sciences. |
| Keywords: | unclassified drug; review; cancer growth; nonhuman; neoplasm; neoplasms; phenotype; animals; imatinib; evolution; cell differentiation; cancer therapy; carcinogenesis; mathematical modeling; carcinogenesiss; cancer resistance; cell heterogeneity; mathematical model; mutator gene; stem cell; models, theoretical |
| Journal Title: | Annals of the New York Academy of Sciences |
| Volume: | 1168 |
| ISSN: | 0077-8923 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2009-06-01 |
| Start Page: | 23 |
| End Page: | 51 |
| Language: | English |
| DOI: | 10.1111/j.1749-6632.2009.04880.x |
| PUBMED: | 19566702 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article in "The Year in Evolutionary Biology 2009" (ISBN: 978-1-57331-754-2) -- "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: ANYAA" - "Source: Scopus" |
