Metastatic insulinoma: Current molecular and cytotoxic therapeutic approaches for metastatic well-differentiated panNETs Journal Article
| Authors: | Giuroiu, I.; Reidy-Lagunes, D. |
| Article Title: | Metastatic insulinoma: Current molecular and cytotoxic therapeutic approaches for metastatic well-differentiated panNETs |
| Abstract: | Pancreatic neuroendocrine tumors (panNETs) are a type of neuroendocrine tumor with 5-year overall survival rates of approximately 50% when metastasis is present at diagnosis. Tumor grade, as defined by Ki-67 proliferation index, influences overall survival, with low-grade tumors portending a better outcome than intermediate-and high-grade tumors. This case report follows the clinical course and management of a patient with an insulin-secreting metastatic panNET who died 10 years after diagnosis after a treatment course with regional therapy and multiple forms of cytotoxic and molecularly targeted agents. This report presents the various treatment options available for patients with insulin-secreting metastatic panNETs. |
| Keywords: | survival; doxorubicin; chemotherapy; liver; metastases; streptozocin; phase-ii; pancreatic neuroendocrine tumors; radioembolization; islet-cell carcinoma; endocrine carcinomas |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 13 |
| Issue: | 2 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2015-02-01 |
| Start Page: | 139 |
| End Page: | 144 |
| Language: | English |
| ACCESSION: | WOS:000349834400005 |
| PROVIDER: | wos |
| PUBMED: | 25691605 |
| Notes: | Article -- Source: Wos |
