Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015 Journal Article

   


Authors: Zelenetz, A. D.; Gordon, L. I.; Wierda, W. G.; Abramson, J. S.; Advani, R. H.; Andreadis, C. B.; Bartlett, N.; Byrd, J. C.; Czuczman, M. S.; Fayad, L. E.; Fisher, R. I.; Glenn, M. J.; Habermann, T. M.; Harris, N. L.; Hoppe, R. T.; Horwitz, S. M.; Kelsey, C. R.; Kim, Y. H.; Krivacic, S.; LaCasce, A. S.; Nademanee, A.; Porcu, P.; Press, O.; Rabinovitch, R.; Reddy, N.; Reid, E.; Saad, A. A.; Sokol, L.; Swinnen, L. J.; Tsien, C.; Vose, J. M.; Wilson, L.; Yahalom, J.; Zafar, N.; Dwyer, M.; Sundar, H.
Article Title: Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015
Abstract: Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease, which are managed in the same way. The advent of novel monoclonal antibodies (ofatumumab and obinutuzumab) led to the development of effective chemoimmunotherapy regimens. The recently approved small molecule kinase inhibitors (ibrutinib and idelalisib) are effective treatment options for CLL in elderly patients with decreased tolerance for aggressive regimens and in patients with poor prognostic features who do not benefit from conventional chemoimmunotherapy regimens. This portion of the NCCN Guidelines for Non-Hodgkin's Lymphomas describes the recent specific to the incorporation of recently approved targeted therapies for the management of patients with newly diagnosed and relapsed or refractory CLL/SLL. © JNCCN-Journal of the National Comprehensive Cancer Network.
Keywords: review; cancer radiotherapy; cancer staging; flow cytometry; antineoplastic agent; cancer diagnosis; practice guideline; patient care; comorbidity; leukemia relapse; chronic lymphatic leukemia; functional status; lymphocytoma; randomized controlled trial (topic); phase 3 clinical trial (topic); cancer prognosis; human
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 13
Issue: 3
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2015-03-01
Start Page: 326
End Page: 362
Language: English
PROVIDER: scopus
PUBMED: 25736010
PMCID: PMC4841457
DOI: 10.6004/jnccn.2015.0045
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84924370528&partnerID=40&md5=1b7156a55764926595b2ee4e44b05b75
Notes: Export Date: 2 April 2015 -- Source: Scopus
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MSK Authors
  1. Joachim Yahalom
    625 Yahalom
  2. Steven M Horwitz
    645 Horwitz
  3. Andrew D Zelenetz
    767 Zelenetz
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