IDH1/2 mutations and BCL-2 dependence: An unexpected chink in AML's armour Journal Article

  


Authors: Pronier, E.; Levine, R. L.
Article Title: IDH1/2 mutations and BCL-2 dependence: An unexpected chink in AML's armour
Abstract: There is a pressing need to develop novel, mechanism-based therapeutic approaches that can be used to improve therapies for genetically defined tumor subtypes. Chan and colleagues have demonstrated recently that BCL-2 inhibitors can target IDH1/2 mutant cancers through a mutant-specific dependency in metabolic regulation. There is a pressing need to develop novel, mechanism-based therapeutic approaches that can be used to improve therapies for genetically defined tumor subtypes. Chan and colleagues have demonstrated recently that BCL-2 inhibitors can target IDH1/2-mutant cancers through a mutant-specific dependency in metabolic regulation. © 2015 Elsevier Inc.
Keywords: acute granulocytic leukemia; gene mutation; mutation; colorectal cancer; protein bcl 2; apoptosis; in vitro study; dna methylation; short survey; chronic lymphatic leukemia; cell metabolism; arginine; cell mutant; molecularly targeted therapy; mitochondrial respiration; isocitrate dehydrogenase 1; histone modification; protein bak; respiratory chain; cell permeabilization; isocitrate dehydrogenase 2; human; priority journal
Journal Title: Cancer Cell
Volume: 27
Issue: 3
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2015-03-09
Start Page: 323
End Page: 325
Language: English
DOI: 10.1016/j.ccell.2015.02.013
PROVIDER: scopus
PUBMED: 25759018
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84924230465&partnerID=40&md5=fedc8649b58dacf0cd7d0b814774648e
Notes: Export Date: 2 April 2015 -- Source: Scopus
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MSK Authors
  1. Ross Levine
    775 Levine
  2. Elodie Pronier
    10 Pronier
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