Indications for neoadjuvant, adjuvant, and palliative chemotherapy in the treatment of biliary tract cancers Journal Article

  


Authors: Huitzil-Melendez, F. D.; O'Reilly, E. M.; Duffy, A.; Abou-Alfa, G. K.
Article Title: Indications for neoadjuvant, adjuvant, and palliative chemotherapy in the treatment of biliary tract cancers
Abstract: Advanced biliary tract carcinomas represent a group of aggressive diseases that still carries a poor prognosis. Chemotherapy has been shown to provide disease control and may also prolong survival. An established role for systemic therapy in the adjuvant setting is still lacking. This article reviews the available evidence to support indications of systemic chemotherapy in the palliative setting and discuss the attempts to study it in the perioperative settings. © 2009 Elsevier Inc. All rights reserved.
Keywords: mitogen activated protein kinase; cancer chemotherapy; cancer surgery; survival rate; overall survival; clinical trial; fatigue; neutropenia; pathogenesis; review; sorafenib; cisplatin; erlotinib; fluorouracil; area under the curve; cancer growth; diarrhea; gastrointestinal hemorrhage; side effect; capecitabine; gemcitabine; adjuvant therapy; chemotherapy, adjuvant; neoadjuvant therapy; chemotherapy; cancer incidence; anorexia; palliative care; carboplatin; infection; multiple cycle treatment; pain; anemia; bone marrow suppression; etoposide; leukopenia; mucosa inflammation; nausea; neuropathy; stomatitis; thrombocytopenia; vomiting; weight reduction; dexamethasone; angiogenesis; abdominal pain; febrile neutropenia; fever; rash; systematic review; thromboembolism; folinic acid; nausea and vomiting; sepsis; cancer registry; epirubicin; mitomycin c; liver cancer; bile duct carcinoma; cholangiocarcinoma; oxaliplatin; hand foot syndrome; lethargy; floxuridine; alopecia; digestive system perforation; gallbladder cancer; fluoropyrimidine; meta analysis; biliary tract cancer; leukoencephalopathy; biliary tract cancers; regional chemotherapy; targeted agents; biliary tract neoplasms
Journal Title: Surgical Oncology Clinics of North America
Volume: 18
Issue: 2
ISSN: 1055-3207
Publisher: Elsevier Inc.  
Date Published: 2009-04-01
Start Page: 361
End Page: 379
Language: English
DOI: 10.1016/j.soc.2008.12.006
PUBMED: 19306817
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-62549102024&partnerID=40&md5=4d932a7b9102d4e3d612d870835e2989
Notes: Book Chapter in Biliary Tract Cancers, J. J. Bennett, ed. (ISBN: 978-1-4377-0912-4); Source: Scopus
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MSK Authors
  1. Fidel David Huitzil Melendez
    11 Huitzil Melendez
  2. Austin Gerard Duffy
    14 Duffy
  3. Ghassan Abou-Alfa
    568 Abou-Alfa
  4. Eileen O'Reilly
    780 O'Reilly
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