Cyclin E amplification/overexpression is associated with poor prognosis in gastric cancer Journal Article
| Authors: | Alsina, M.; Landolfi, S.; Aura, C.; Caci, K.; Jimenez, J.; Prudkin, L.; Castro, S.; Moreno, D.; Navalpotro, B.; Tabernero, J.; Scaltriti, M. |
| Article Title: | Cyclin E amplification/overexpression is associated with poor prognosis in gastric cancer |
| Abstract: | We describe the correlation between cyclin E and HER2 amplification/overexpression and the clinical outcome in 87 patients with gastric cancer (GC) treated with surgery and adjuvant treatment at our centre. We observed that cyclin E and HER2 amplification/overexpression are not mutually exclusive, and that cyclin E amplification/overexpression correlates with poor prognosis. The co-amplification of cyclin E and HER2 in GC warrants prospective evaluation given the reported role of cyclin E in limiting the effectiveness of anti-HER2 therapies. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. |
| Journal Title: | Annals of Oncology |
| Volume: | 26 |
| Issue: | 2 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2015-02-01 |
| Start Page: | 438 |
| End Page: | 439 |
| Language: | English |
| DOI: | 10.1093/annonc/mdu535 |
| PROVIDER: | scopus |
| PUBMED: | 25403579 |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2015 -- Source: Scopus |
