Hedgehog signaling in prostate epithelial-mesenchymal growth regulation Journal Article


Authors: Peng, Y. C.; Joyner, A. L.
Article Title: Hedgehog signaling in prostate epithelial-mesenchymal growth regulation
Abstract: The prostate gland plays an important role in male reproduction, and is also an organ prone to diseases such as benign prostatic hyperplasia (BPH) and prostate cancer. The prostate consists of ducts with an inner layer of epithelium surrounded by stroma. Reciprocal signaling between these two cell compartments is instrumental to normal prostatic development, homeostasis, regeneration, as well as tumor formation. Hedgehog (HH) signaling is a master regulator in numerous developmental processes. In many organs, HH plays a key role in epithelial-mesenchymal signaling that regulates organ growth and tissue differentiation, and abnormal HH signaling has been implicated in the progression of various epithelial carcinomas. In this review, we focus on recent studies exploring the multipotency of endogenous postnatal and adult epithelial and stromal stem cells and studies addressing the role of HH in prostate development and cancer. We discuss the implications of the results for a new understanding of prostate development and disease. Insight into the cellular and molecular mechanisms underlying epithelial-mesenchymal growth regulation should provide a basis for devising innovative therapies to combat diseases of the prostate. © 2015 Elsevier Inc.
Keywords: signal transduction; protein expression; nonhuman; sonic hedgehog protein; tissue regeneration; carcinogenesis; stem cell; prostate cancer; prostate; growth regulation; stroma; stem cells; multipotent stem cell; erinaceidae; adult stem cell; tissue differentiation; organogenesis; postnatal development; epithelial mesenchymal transition; shh; human; priority journal; article; epithelial-mesenchymal interaction; epithelial stem cell; stromal stem cell
Journal Title: Developmental Biology
Volume: 400
Issue: 1
ISSN: 0012-1606
Publisher: Elsevier Inc.  
Date Published: 2015-04-01
Start Page: 94
End Page: 104
Language: English
DOI: 10.1016/j.ydbio.2015.01.019
PROVIDER: scopus
PMCID: PMC4361250
PUBMED: 25641695
DOI/URL:
Notes: Export Date: 2 April 2015 -- Source: Scopus
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MSK Authors
  1. Alexandra L Joyner
    80 Joyner
  2. Yu-Ching   Peng
    5 Peng