Adjuvant and neoadjuvant systemic therapy for pancreas adenocarcinoma Journal Article
| Authors: | Li, D.; O'Reilly, E. M. |
| Article Title: | Adjuvant and neoadjuvant systemic therapy for pancreas adenocarcinoma |
| Abstract: | The last two decades of research in the adjuvant setting of pancreas adenocarcinoma have established the value of adjuvant systemic therapy as being able to delay recurrence and increase overall survival. International standards of care in the adjuvant setting include either 6 months of gemcitabine or 5-flurouracil and leucovorin. The added value of additional agents in the adjuvant setting is being evaluated in several large adjuvant studies. The role of a targeted agent in the adjuvant setting remains investigational. Other major areas of exploration include the integration of adjuvant immunotherapeutic approaches, which provide promise in a setting of micrometastatic disease volumes where such approaches may have greatest value. © 2015 Elsevier Inc. All rights reserved. |
| Keywords: | treatment response; cancer surgery; overall survival; cisplatin; erlotinib; fluorouracil; cancer combination chemotherapy; drug efficacy; drug safety; multimodality cancer therapy; patient selection; systemic therapy; capecitabine; gemcitabine; paclitaxel; cancer adjuvant therapy; cancer patient; cancer radiotherapy; disease free survival; pancreas resection; antineoplastic agent; biological marker; cancer immunotherapy; tumor volume; irinotecan; cancer vaccine; systematic review; folinic acid; adjuvant chemotherapy; cancer immunization; pancreas adenocarcinoma; granulocyte macrophage colony stimulating factor vaccine; oxaliplatin; fluoropyrimidine; disease specific survival; chemoradiotherapy; randomized controlled trial (topic); phase 3 clinical trial (topic); multicenter study (topic); tertomotide; gimeracil plus oteracil potassium plus tegafur; human; priority journal; article; algenpantucel l |
| Journal Title: | Seminars in Oncology |
| Volume: | 42 |
| Issue: | 1 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-02-01 |
| Start Page: | 134 |
| End Page: | 143 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2014.12.012 |
| PROVIDER: | scopus |
| PUBMED: | 25726058 |
| PMCID: | PMC4991774 |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2015 -- Source: Scopus |
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