Evaluation of hypoxia with copper-labeled diacetyl-bis(N-Methylthiosemicarbazone) Journal Article
| Authors: | Lapi, S. E.; Lewis, J. S.; Dehdashti, F. |
| Article Title: | Evaluation of hypoxia with copper-labeled diacetyl-bis(N-Methylthiosemicarbazone) |
| Abstract: | Imaging of hypoxia is important in many diseases states in oncology, cardiology, and neurology. The radiopharmaceutical, copper-labeled diacetyl-bis(N-methylthiosemicarbazone), has been used to assess hypoxia in many studies. In particular, copper-labeled diacetyl-bis(N-methylthiosemicarbazone) has been used in oncologic settings to investigate tumor hypoxia and the role of this parameter in response to therapy and outcome. Some groups have conducted imaging studies assessing the role of hypoxia in cardiovascular and neurologic disorders. Additionally, several groups have made significant progress into understanding the mechanism by which this compound accumulates in cells. Multiple preclinical and clinical studies have been conducted, shedding light on the importance of careful image analysis when using this tracer. This review article focuses on the recent preclinical and clinical studies with this tracer. © 2015 Elsevier Inc. |
| Keywords: | vasculotropin; unclassified drug; intensity modulated radiation therapy; nonhuman; positron emission tomography; vasculotropin receptor; hypoxia; carbonate dehydratase ix; head and neck cancer; cyclooxygenase 2; fluorodeoxyglucose f 18; computer assisted emission tomography; radiopharmaceutical agent; rectum cancer; neurologic disease; coronary artery disease; heart muscle ischemia; corpus striatum; disease activity; glucose metabolism; article; diacetyl bis(n methylthiosemicarbazone) cu 60; diacetyl bis(n methylthiosemicarbazone) cu 62 |
| Journal Title: | Seminars in Nuclear Medicine |
| Volume: | 45 |
| Issue: | 2 |
| ISSN: | 0001-2998 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-03-01 |
| Start Page: | 177 |
| End Page: | 185 |
| Language: | English |
| DOI: | 10.1053/j.semnuclmed.2014.10.003 |
| PROVIDER: | scopus |
| PMCID: | PMC4339100 |
| PUBMED: | 25704389 |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2015 -- Source: Scopus |
