Premalignant cystic neoplasms of the pancreas Journal Article
| Authors: | Dudeja, V.; Allen, P. J. |
| Article Title: | Premalignant cystic neoplasms of the pancreas |
| Abstract: | Due to increasing utilization of cross-sectional imaging, asymptomatic pancreatic cysts are frequently being diagnosed. Many of these cysts have premalignant potential and offer a unique opportunity for cancer prevention. Mucinous cystic neoplasm and intraductal papillary mucinous neoplasm are the major premalignant cystic neoplasms of pancreas. The prediction of the risk of malignancy (incidental and future risk of malignant transformation) and balancing the risks of watchful waiting with that of operative management with associated mortality and morbidity is the key to the management of these lesions. We review the literature that has contributed to the development of our approach to the management of these cystic neoplasms. We provide an overview of the key features used in diagnosis and in predicting malignancy. Particular attention is given to the natural history and management decision making. © 2015 Elsevier Inc. All rights reserved. |
| Keywords: | gene mutation; clinical feature; histopathology; pathogenesis; disease classification; nonhuman; pathophysiology; pancreas resection; nuclear magnetic resonance imaging; sensitivity and specificity; pancreaticoduodenectomy; treatment indication; diagnostic procedure; tumor localization; computer assisted tomography; tumor volume; prevalence; cystadenoma; intraductal papillary mucinous tumor; pancreas cyst; cyst fluid; cancer therapy; risk factor; cancer genetics; diagnostic value; pancreas tumor; pancreas adenocarcinoma; clinical decision making; endoscopic retrograde cholangiopancreatography; multidetector computed tomography; mucinous cystic neoplasm; pancreas pseudocyst; diagnostic test accuracy study; tumor invasion; magnetic resonance cholangiopancreatography; pancreas adenoma; cystic neoplasm; human; priority journal; article; pancreas cystic neoplasm |
| Journal Title: | Seminars in Oncology |
| Volume: | 42 |
| Issue: | 1 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-02-01 |
| Start Page: | 70 |
| End Page: | 85 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2014.12.007 |
| PROVIDER: | scopus |
| PUBMED: | 25726053 |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2015 -- Source: Scopus |
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