Double-strand breaks and translocations in cancer Journal Article
| Authors: | Elliott, B.; Jasin, M. |
| Article Title: | Double-strand breaks and translocations in cancer |
| Abstract: | The correct repair of double-strand breaks (DSBs) is essential for the genomic integrity of a cell, as inappropriate repair can lead to chromosomal rearrangements such as translocations. In many hematologic cancers and sarcomas, translocations are the etiological factor in tumorigenesis, resulting in either the deregulation of a proto-oncogene or the expression of a fusion protein with transforming properties. Mammalian cells are able to repair DSBs by pathways involving homologous recombination and nonhomologous end-joining. The analysis of translocation breakpoints in a number of cancers and the development of model translocation systems are beginning to shed light on specific DSB repair pathway(s) responsible for the improper repair of broken chromosomes. |
| Keywords: | chronic myelogenous leukemia; double-strand breaks; recombination; acute lymphoblastic-leukemia; translocations; rna-binding protein; chromosomal; philadelphia-chromosome; tyrosine kinase-activity; round-cell tumor; burkitt-lymphoma cells; cancer; heavy-chain locus; c-myc oncogene; dna repair pathways |
| Journal Title: | Cellular and Molecular Life Sciences |
| Volume: | 59 |
| Issue: | 2 |
| ISSN: | 1420-682X |
| Publisher: | Springer |
| Date Published: | 2002-02-01 |
| Start Page: | 373 |
| End Page: | 385 |
| Language: | English |
| ACCESSION: | WOS:000174156600015 |
| DOI: | 10.1007/s00018-002-8429-3 |
| PROVIDER: | wos |
| PUBMED: | 11915950 |
| Notes: | Review -- Source: Wos |
