Imposing specificity by localization: Mechanism and evolvability Conference Paper
| Authors: | Ptashne, M.; Gann, A. |
| Title: | Imposing specificity by localization: Mechanism and evolvability |
| Conference Title: | 1999 DIMACS Workshop on Evolution as Computation |
| Abstract: | Cells detect extracellular signals by allostery and then give those signals meaning by "regulated localization". We suggest that this formulation applies to many biological processes and is particularly well illustrated by the mechanisms of gene regulation. Analysis of these mechanisms reveals that regulated localization requires simple molecular interactions that are readily used combinatorially. This system of regulation is highly "evolvable", and its use accounts, at least in part, for the nature of the complexities observed in biological systems. |
| Keywords: | yeast; transcriptional activation; nucleosome; pathway; recruitment; signal-transduction; receptor protein; gene-regulation; bacteriophage-lambda; polymerase-ii holoenzyme |
| Journal Title | Natural Computing Series |
| Conference Dates: | 1999 Jan 11-12 |
| Conference Location: | Princeton, NJ |
| ISBN: | 1619-7127 |
| Publisher: | Springer Verlag |
| Location: | Berlin |
| Date Published: | 2002-01-01 |
| Start Page: | 179 |
| End Page: | 200 |
| Language: | English |
| ACCESSION: | WOS:000180831300010 |
| PROVIDER: | wos |
| DOI: | 10.1007/978-3-642-55606-7_9 |
| Notes: | Chapter in "Evolution as Computation" (ISBN: 978-3-642-63081-1) -- Source: Wos |
