Current status and future potential role of exemestane in the treatment of early and advanced breast cancer (Review) Journal Article
| Authors: | Crucitta, E.; Fornier, M. N.; Locopo, N.; Silvestris, N.; Lorusso, V.; De Lena, M. |
| Article Title: | Current status and future potential role of exemestane in the treatment of early and advanced breast cancer (Review) |
| Abstract: | Exemestane is a new oral steroidal aromatase inactivator, active in postmenopausal women with hormonal sensitive breast carcinoma. This drug, at a dosage of 25 mg once daily, was shown to suppress it? vivo aromatase activity by 97.9%, with a subsequent reduction superior to 85% of circulating oestrogen level. It exhibits definite antitumor activity at a relatively low daily dose, and is highly potent, highly selective, and well-tolerated. Moreover, for postmenopausal women with metastatic breast cancer, exemestane demonstrated a higher activity and lower toxicity profile when compared to megestrol acetate and tamoxifen in second- and first-line therapy, respectively. New data on exemestane are forthcoming both in the adjuvant and neoadjuvant setting, which could improve the management of early breast cancer in the future. |
| Keywords: | breast cancer; exemestane; experience; tamoxifen; aromatase inhibitors; therapy; neoadjuvant; metastatic disease; trial; adjuvant; phase-i; postmenopausal women; endocrine |
| Journal Title: | International Journal of Oncology |
| Volume: | 20 |
| Issue: | 6 |
| ISSN: | 1019-6439 |
| Publisher: | Spandidos Publications |
| Date Published: | 2002-06-01 |
| Start Page: | 1283 |
| End Page: | 1288 |
| Language: | English |
| ACCESSION: | WOS:000175631400025 |
| PROVIDER: | wos |
| PUBMED: | 12012011 |
| DOI: | 10.3892/ijo.20.6.1283 |
| Notes: | Article -- Source: Wos |
