p53 de-ubiquitination: At the edge between life and death Journal Article
| Authors: | Salomoni, P.; Pandolfi, P. P. |
| Article Title: | p53 de-ubiquitination: At the edge between life and death |
| Abstract: | The tumour suppressor protein p53 is stabilized by the de-ubiquitination enzyme herpes-virus-associated ubiquitin-specific protease (HAUSP), which localizes to the promyelocytic leukaemia nuclear body (PML-NB). The pro-apoptotic activity of p53 is also induced by HAUSP. Therefore, p53 ubiquitination is a dynamic process, and HAUSP might function as a tumour suppressor by enhancing p53 stabilization. |
| Keywords: | controlled study; unclassified drug; note; ubiquitin; protein function; animals; cell survival; apoptosis; protein stability; protein p53; tumor suppressor gene; promyelocytic leukemia; herpes virus; herpesviridae; tumor suppressor protein p53; proteinase; mammals; enzyme localization; cell nucleus inclusion body; priority journal; protein hausp |
| Journal Title: | Nature Cell Biology |
| Volume: | 4 |
| Issue: | 6 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-06-01 |
| Start Page: | E152 |
| End Page: | E153 |
| Language: | English |
| DOI: | 10.1038/ncb0602-e152 |
| PUBMED: | 12042830 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
