EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: Presentation of a case Journal Article
| Authors: | Yancoskie, A. E.; Sreekantaiah, C.; Jacob, J.; Rosenberg, A.; Edelman, M.; Antonescu, C. R.; Fantasia, J. E. |
| Article Title: | EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: Presentation of a case |
| Abstract: | Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws that is more common in the mandible than maxilla and has a female preponderance with a peak incidence in the sixth decade. It is characterized by locally aggressive behavior and has the potential to metastasize. This tumor was recently reported to have a rearrangement of the Ewing sarcoma breakpoint region 1 gene (EWS RNA-binding protein 1, EWSR1) in 5 of 8 cases tested and of the activating transcription factor 1 gene (ATF1) in 1 case tested. We report a case of CCOC in the premolar area of the mandible in a 59-year-old woman. This case demonstrated the presence of both EWSR1 and ATF1 gene rearrangements by fluorescence in situ hybridization. |
| Journal Title: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
| Volume: | 118 |
| Issue: | 4 |
| ISSN: | 2212-4403 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2014-10-01 |
| Start Page: | e115 |
| End Page: | e118 |
| Language: | English |
| DOI: | 10.1016/j.oooo.2014.02.004 |
| PROVIDER: | scopus |
| PUBMED: | 24721473 |
| DOI/URL: | |
| Notes: | Export Date: 2 March 2015 -- Source: Scopus |
