Hepatic artery infusion chemotherapy for liver malignancy Journal Article
| Authors: | Leal, J. N.; Kingham, T. P. |
| Article Title: | Hepatic artery infusion chemotherapy for liver malignancy |
| Abstract: | To date, hepatic artery infusion (HAI) chemotherapy has primarily been investigated in the setting of colorectal cancer liver metastases (CRLM). Few studies have been conducted in North America regarding HAI chemotherapy for primary liver cancers (PLC) or noncolorectal liver metastases (non-CRLM). Despite decades of evaluation, controversy surrounding the use of HAI chemotherapy still exists. In this article the methods of HAI chemotherapy delivery, technical aspects of catheter and pump insertion, and specific complications of HAI chemotherapy are discussed. Outcomes of clinical trials and reviews of HAI chemotherapy in the setting of CRLM, PLC, and non-CRLM are evaluated. |
| Keywords: | cancer chemotherapy; treatment outcome; neutropenia; review; bevacizumab; cisplatin; doxorubicin; fluorouracil; diarrhea; drug dose reduction; liver cell carcinoma; patient selection; capecitabine; adjuvant therapy; cancer adjuvant therapy; disease free survival; postoperative care; methylene blue; interleukin 2; infection; bleeding; mucosa inflammation; nausea; stomatitis; vomiting; dexamethasone; irinotecan; drug dose escalation; liver metastasis; folinic acid; liver resection; liver disease; liver cancer; bile duct carcinoma; hyperbilirubinemia; mitomycin; oxaliplatin; hematoma; floxuridine; prosthesis loosening; artery thrombosis; drug delivery system; hepatic artery; fluorescein; liver metastases; randomized controlled trial (topic); biliary tract disease; phase 2 clinical trial (topic); infusion pump; liver perfusion; phase 1 clinical trial (topic); catheter occlusion; artery dissection; erosion; regional therapy; biliary sclerosis; toxic hepatitis; artery catheter; enzyme defect; colorectal liver metastasis; medical device complication; human; liver-directed therapy; primary liver cancer; catheter migration; extrahepatic perfusion; hepatic artery infusion chemotherapy; incomplete hepatic perfusion; pump migration |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 24 |
| Issue: | 1 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-01-01 |
| Start Page: | 121 |
| End Page: | 148 |
| Language: | English |
| DOI: | 10.1016/j.soc.2014.09.005 |
| PROVIDER: | scopus |
| PUBMED: | 25444472 |
| DOI/URL: | |
| Notes: | Export Date: 2 March 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work