Critical review of current treatment strategies for advanced hormone insensitive breast cancer Journal Article
| Authors: | Van Poznak, C.; Seidman, A. D. |
| Article Title: | Critical review of current treatment strategies for advanced hormone insensitive breast cancer |
| Abstract: | Breast cancer is the most common cancer diagnosis in American women. Over the past several decades, there has been a steady increase in the incidence of this disease. Fortunately, the death rates in the last decade has showed a decrease. Patients with breast cancer now have more treatment options and a better chance of long term survival than ever before. Patients with metastatic disease are considered candidates for chemotherapy if they are symptomatic, have rapidly progressing or bulky disease, or if they are inappropriate candidates for hormonal therapy either because of negative hormonal receptor status or progression of disease on hormonal therapies. Patients are often treated with a chemotherapy regimen until progression of disease, or prohibitive toxicity, at which time the therapy is changed to a second or a third line therapy. This manuscript will provide a review of the current treatment strategies for advanced hormone insensitive breast cancer. |
| Keywords: | cancer survival; treatment outcome; oncoprotein; prednisone; clinical trial; fatigue; salvage therapy; cisplatin; doxorubicin; fluorouracil; advanced cancer; cancer combination chemotherapy; diarrhea; antineoplastic agents; conference paper; capecitabine; gemcitabine; paclitaxel; cancer patient; chemotherapy; methotrexate; neurotoxicity; carboplatin; quality of life; infection; breast cancer; bone marrow suppression; etoposide; mucosa inflammation; nausea; vomiting; antineoplastic combined chemotherapy protocols; drug administration schedule; incidence; alkylating agent; cyclophosphamide; melphalan; vincristine; antineoplastic activity; drug effect; drug resistance, neoplasm; breast neoplasms; ifosfamide; thiotepa; vinblastine; docetaxel; cancer hormone therapy; febrile neutropenia; antibodies, monoclonal; immunotherapy; disease progression; cardiotoxicity; mitoxantrone; neoplasm metastasis; epirubicin; mitomycin c; platinum; receptors, estrogen; receptors, progesterone; vinca alkaloid; taxane derivative; trastuzumab; navelbine; oxaliplatin; breast metastasis; hand foot syndrome; alopecia; clinical trials; antimetabolite; hormone resistance; goals; metastatic; oncogene neu; anthracycline antibiotic agent; humans; human; female; priority journal; evacet |
| Journal Title: | Cancer Investigation |
| Volume: | 20 |
| Issue: | Suppl.2 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 2002-01-01 |
| Start Page: | 1 |
| End Page: | 14 |
| Language: | English |
| PUBMED: | 12442344 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
