Risk-adapted therapy for relapsed and refractory lymphoma using ICE chemotherapy Journal Article
| Author: | Moskowitz, C. |
| Article Title: | Risk-adapted therapy for relapsed and refractory lymphoma using ICE chemotherapy |
| Abstract: | At Memorial Sloan Kettering Cancer Center, New York, we have treated over 400 patients with ICE chemotherapy after failure of upfront anthracycline-based therapy with a response rate of 72% in aggressive non-Hodgkin's lymphoma (NHL) and 84% in Hodgkin's disease. Utilizing this database, we have identified pretreatment prognostic markers capable of predicting the quality of response (complete response vs partial response vs failure) to second-line cytoreductive ICE chemotherapy and consequently autologous stem cell transplantation. We have shown that in aggressive NHL, patients achieving a complete response have superior survival when compared to those achieving only a partial response. By identifying a priori those patients destined to have only a partial response to ICE, we will be able to target a group of chemosensitive patients who are most likely to benefit from improved treatment. Novel treatment strategies designed to increase their complete response rate would be anticipated to improve their long-term survival. |
| Keywords: | cancer chemotherapy; cancer survival; treatment outcome; disease-free survival; treatment failure; clinical trial; cancer recurrence; dose response; drug safety; nonhuman; conference paper; cancer radiotherapy; carboplatin; etoposide; antineoplastic combined chemotherapy protocols; drug administration schedule; stem cell transplantation; chemosensitivity; data base; prediction; ifosfamide; hodgkin disease; radiation response; risk; survival time; lymphoma, b-cell; nonhodgkin lymphoma; randomized controlled trials; lymphoma, non-hodgkin; anthracycline; ice chemotherapy; humans; prognosis; human; priority journal; risk-adapted therapy; refractory lymphoma |
| Journal Title: | Cancer Chemotherapy and Pharmacology |
| Volume: | 49 |
| Issue: | 1 Suppl. |
| ISSN: | 0344-5704 |
| Publisher: | Springer |
| Date Published: | 2002-04-01 |
| Start Page: | S9 |
| End Page: | S12 |
| Language: | English |
| PUBMED: | 12042983 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s00280-002-0446-2 |
| DOI/URL: | |
| Notes: | Presented at ECCO's 11th Meeting; 2001 Oct 21; Lisbon, Portugal -- Export Date: 14 November 2014 -- Source: Scopus |
