Using direct force measurements to determine the mechanism of neural cell adhesion molecule (NCAM) function Conference Paper


Authors: Leckband, D.; Johnson, C.; Roberts, R.; Fujimoto, I.; Anderson, B.; Rutishauser, U.
Title: Using direct force measurements to determine the mechanism of neural cell adhesion molecule (NCAM) function
Conference Title: 2nd Joint EMBS/BMES Conference
Abstract: The molecular mechanism of homophilic adhesion between neural cell adhesion molecules (NCAM) was investigated by direct force measurements. The force-distance profiles demonstrated that multiple domains are involved in adhesion. In addition, the effect of polysialylation on the interprotein forces provided insights into the molecular mechanism by which posttranslational modification regulates NCAM function.
Keywords: proteins; polysialic acid; cell membranes; surface plasmon resonance; adhesion; neural cell adhesion molecule; post-translational modification; polysialylation; distance measurement; force measurement; immunoglobulin domains
Journal Title IEEE Engineering in Medicine and Biology Society. Annual International Conference. Proceedings
Volume: 1
Conference Dates: 2002 Oct 23-26
Conference Location: Houston, TX
ISBN: 1094-687X
Publisher: IEEE  
Date Published: 2002-10-01
Start Page: 339
End Page: 340
Language: English
PROVIDER: scopus
DOI: 10.1109/IEMBS.2002.1134524
DOI/URL:
Notes: Annu Int Conf IEEE Eng Med Biol Proc -- Conference code: 60460 -- Export Date: 14 November 2014 -- CODEN: CEMBA -- 23 October 2002 through 26 October 2002 -- Source: Scopus
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