Authors: | Leckband, D.; Johnson, C.; Roberts, R.; Fujimoto, I.; Anderson, B.; Rutishauser, U. |
Title: | Using direct force measurements to determine the mechanism of neural cell adhesion molecule (NCAM) function |
Conference Title: | 2nd Joint EMBS/BMES Conference |
Abstract: | The molecular mechanism of homophilic adhesion between neural cell adhesion molecules (NCAM) was investigated by direct force measurements. The force-distance profiles demonstrated that multiple domains are involved in adhesion. In addition, the effect of polysialylation on the interprotein forces provided insights into the molecular mechanism by which posttranslational modification regulates NCAM function. |
Keywords: | proteins; polysialic acid; cell membranes; surface plasmon resonance; adhesion; neural cell adhesion molecule; post-translational modification; polysialylation; distance measurement; force measurement; immunoglobulin domains |
Journal Title | IEEE Engineering in Medicine and Biology Society. Annual International Conference. Proceedings |
Volume: | 1 |
Conference Dates: | 2002 Oct 23-26 |
Conference Location: | Houston, TX |
ISBN: | 1094-687X |
Publisher: | IEEE |
Date Published: | 2002-10-01 |
Start Page: | 339 |
End Page: | 340 |
Language: | English |
PROVIDER: | scopus |
DOI: | 10.1109/IEMBS.2002.1134524 |
DOI/URL: | |
Notes: | Annu Int Conf IEEE Eng Med Biol Proc -- Conference code: 60460 -- Export Date: 14 November 2014 -- CODEN: CEMBA -- 23 October 2002 through 26 October 2002 -- Source: Scopus |