Cytolytic pathways in haematopoietic stem-cell transplantation Journal Article
| Authors: | van den Brink, M. R. M.; Burakoff, S. J. |
| Article Title: | Cytolytic pathways in haematopoietic stem-cell transplantation |
| Abstract: | The remarkable activity of donor T cells against malignant cells in the context of an allogeneic haematopoietic stem-cell transplantation (HSCT) is arguably, at present, the most potent clinical immunotherapy for cancer. However, alloreactive donor T cells are also important effector cells in the development of graft-versus-host disease (GVHD), which is a potentially lethal complication for recipients of an allogeneic HSCT. Therefore, the separation of the GVHD and graft-versus-tumour (GVT) activity of donor T cells has become a topic of great interest for many investigators. Recent studies have shown that donor T cells make differential use of their cytolytic pathways in mediating GVHD and GVT effects. Therefore, the selective blockade or enhancement of cytolytic pathways provides an intriguing therapeutic opportunity to separate the desired GVT effect from the potentially devastating GVHD. |
| Keywords: | allograft; transplantation, homologous; unclassified drug; review; nonhuman; neoplasm; neoplasms; t lymphocyte; t-lymphocytes; animal; animals; cancer immunotherapy; fas antigen; fas ligand; hematopoietic stem cell transplantation; antineoplastic activity; cytotoxicity; stem cell; immunological tolerance; immunology; graft versus host reaction; stem cells; donor lymphocyte infusion; perforin; cytolysis; cytotoxicity, immunologic; graft vs host disease; cell interaction; graft versus leukemia effect; graft vs tumor effect; cell transfer; allotransplantation; enzyme; tumor cell destruction; bone marrow purging; conditioning regimen; scleroderma; granzyme; humans; human; priority journal; nonmyeloablative allogeneic hematopoietic stem cell transplantation |
| Journal Title: | Nature Reviews Immunology |
| Volume: | 2 |
| Issue: | 4 |
| ISSN: | 1474-1733 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-04-01 |
| Start Page: | 273 |
| End Page: | 281 |
| Language: | English |
| PUBMED: | 12001998 |
| PROVIDER: | scopus |
| DOI: | 10.1038/nri775 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
