Sphingolipids, apoptosis, cancer treatments and the ovary: Investigating a crime against female fertility Journal Article
| Authors: | Tilly, J. L.; Kolesnick, R. N. |
| Article Title: | Sphingolipids, apoptosis, cancer treatments and the ovary: Investigating a crime against female fertility |
| Abstract: | Premature ovarian failure and infertility are well-known side-effects observed in young girls and reproductive-age women treated for cancer. Although the need for tumor eradication in these patients is clear, the long-term consequences of chemotherapy and radiation on non-target tissues, such as the ovaries where large numbers of germ cells (oocytes) are also killed off, are substantial. Unfortunately, the mechanism mediating the undesirable toxicity of cancer therapies in the female gonads has only recently been explored. Nevertheless, some important insights into the role of ceramide and sphingosine-1-phosphate (S1P) as a mediator and suppressor, respectively, of cancer therapy-induced oocyte apoptosis have emerged over the past few years. Such findings are exciting in that a better understanding of the crime - how radiation and chemotherapy kill off this irreplaceable population of innocent cells in the ovaries - may finally allow for the development of novel lipid-based strategies to combat infertility and premature menopause in female cancer patients. © 2002 Elsevier Science B.V. All rights reserved. |
| Keywords: | cancer chemotherapy; pathogenesis; review; doxorubicin; dose response; nonhuman; antineoplastic agents; cancer patient; cancer radiotherapy; drug megadose; antineoplastic agent; oocyte; animals; oocytes; cell death; apoptosis; radiotherapy; membrane proteins; cell population; cancer therapy; infertility; ovary; drug mechanism; radiation-protective agents; sphingolipids; sphingosine; fertility; phosphoric monoester hydrolases; gonad; female infertility; ceramide; ceramides; mediator; sphingosine 1 phosphate; n,n dimethylsphingosine; early menopause; sphingosine-1-phosphate; fumonisin b1; target organ; chronic toxicity; humans; human; female; priority journal |
| Journal Title: | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids |
| Volume: | 1585 |
| Issue: | 2-3 |
| ISSN: | 1388-1981 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2002-12-30 |
| Start Page: | 135 |
| End Page: | 138 |
| Language: | English |
| DOI: | 10.1016/s1388-1981(02)00333-5 |
| PUBMED: | 12531546 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
