Emergence of multidrug resistance in leukemia cells during chemotherapy: Mechanisms and prevention Journal Article
| Author: | Shtil, A. A. |
| Article Title: | Emergence of multidrug resistance in leukemia cells during chemotherapy: Mechanisms and prevention |
| Abstract: | Multifactorial resistance to extracellular stimuli is one of the major factors of tumor progression. Cells can acquire a multidrug resistant (MDR) phenotype in response to a wide variety of stress-inducing agents including chemotherapeutic drugs. In addition to the mechanisms expressed in the tumor prior to chemotherapy (presumably these mechanisms allowed tumor cells to escape the control of growth and differentiation), a complex phenotype of pleiotropic resistance is presented in the residual or recurrent tumor. This review analyzes the molecular mechanisms of MDR acquisition with the focus on hematopoietic malignancies. In particular, the chemotherapy- induced up-regulation of P-glycoprotein, a broad- specificity transmembrane efflux pump, is considered a major event in establishment of MDR in leukemia cells that were sensitive before drug exposure. The pharmacological and genetic approaches to prevent the acquisition of Pgp-mediated MDR during chemotherapy are discussed. |
| Keywords: | signal transduction; cancer chemotherapy; acute granulocytic leukemia; hydroxyurea; review; cisplatin; doxorubicin; fluorouracil; drug efficacy; nonhuman; cytarabine; antineoplastic agent; phenotype; gene; unindexed drug; transcription initiation; transcription factor; vincristine; immunoglobulin enhancer binding protein; messenger rna; chromatin; acetylsalicylic acid; ibuprofen; sulindac; leukemia cell; dactinomycin; protein kinase c; adenosine triphosphate; trabectedin; retinoid; diacylglycerol; multidrug resistance; complementary dna; trichostatin a; glycoprotein p; rhodamine 123; staurosporine; xenobiotic agent; salicylate sodium; human; priority journal; piroxicam; 1 (5 isoquinolinesulfonyl) 2 methylpiperazine; alpha amanitin |
| Journal Title: | Journal of Hematotherapy and Stem Cell Research |
| Volume: | 11 |
| Issue: | 2 |
| ISSN: | 1525-8165 |
| Publisher: | Mary Ann Liebert, Inc |
| Date Published: | 2002-04-01 |
| Start Page: | 231 |
| End Page: | 241 |
| Language: | English |
| DOI: | 10.1089/152581602753658439 |
| PROVIDER: | scopus |
| PUBMED: | 11983096 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
