The case for polyvalent cancer vaccines that induce antibodies Journal Article

  


Authors: Ragupathi, G.; Livingston, P.
Article Title: The case for polyvalent cancer vaccines that induce antibodies
Abstract: Antibodies are ideally suited for eradicating pathogens from the bloodstream and early tissue invasion. With regard to cancer cells, passively administered and vaccine induced antibodies have accomplished this, eliminating circulating tumor cells and systemic or intraperitoneal micrometastases in a variety of preclinical models. A series of cancer cell-surface differentiation antigens have now been identified and synthesized. Antibodies against each can be induced in most vaccinated patients using keyhole limpet hemocyanin conjugate vaccines with a potent immunological adjuvant. Polyvalent vaccines may be required due to tumor cell heterogeneity, heterogeneity of the human immune response and the correlation between overall antibody titer against tumor cells and antibody effector mechanisms. Trials testing the clinical impact of these polyvalent vaccines in the adjuvant setting are planned for the near future.
Keywords: cancer survival; unclassified drug; clinical trial; review; nonhuman; drug targeting; follow up; neoplasms; animals; bcg vaccine; melanoma; ovary cancer; breast cancer; cyclophosphamide; tumor antigen; genetic transduction; cell heterogeneity; monoclonal antibody; prostate cancer; sarcoma; cancer invasion; lung small cell cancer; membrane antigen; prostate specific membrane antigen; correlation analysis; immune response; antigens, neoplasm; cancer vaccine; drug mechanism; cancer vaccines; neuroblastoma; ganglioside gd2; colon cancer; epitope; cytotoxic t lymphocyte; immunological adjuvant; plant extract; ganglioside gm1; mucin 1; ca 125 antigen; antibodies, neoplasm; antibody; ganglioside gd3; ganglioside gm2; vaccine; antigens, surface; antibody titer; keyhole limpet hemocyanin; mucin; globo h antigen; qs 21; adjuvant; ganglioside; bark; quillaja saponaria extract; quillaja saponaria; covalent bond; conjugate; polyvalent; phosphoryl lipid a; thomsen friedenreich antigen; cancer; humans; human; priority journal; ganglioside gd2l; ganglioside gd3l; sialyl lewis y antigen
Journal Title: Expert Review of Vaccines
Volume: 1
Issue: 2
ISSN: 1476-0584
Publisher: Informa Healthcare  
Date Published: 2002-08-01
Start Page: 193
End Page: 206
Language: English
DOI: 10.1586/14760584.1.2.193
PUBMED: 12901558
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0037501163&partnerID=40&md5=12a3ab0dcff69d12504b3047e3b39d00
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. Govindaswami Ragupathi
    144 Ragupathi
  2. Philip O Livingston
    228 Livingston
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