| Abstract: |
Idiopathic dilated cardiomyopathy (IDC) is a distinct disease of the myocardium, of unknown etiology. The disease can occur acutely, or evolve in a subacute fashion. IDC is often associated with a substantial impairment of ventricular function, which may recover over time. Although spontaneous recovery of LV function occurs in 20%-45% of newly diagnosed patients, the majority of patients do not do well. IDC has an average 5-year mortality of 20%. Abnormalities of energetics, perfusion, and adrenergic control of the myocardium are markers of the status of LV dysfunction. As the heart fails, changes occur in the production and catabolism of high-energy substrates, the efficiency of mitochondrial oxidative processes, the distribution of resting perfusion and coronary vasodilating capacity and the adrenergic receptor density and function. This article reviews the information provided by metabolic and receptor imaging in patients with IDC, and the role the data may play in patient management. |
| Keywords: |
controlled study; unclassified drug; disease course; mortality; review; heart left ventricle failure; disease marker; pathophysiology; positron emission tomography; radiopharmaceuticals; protein function; metabolism; diagnostic imaging; patient care; diagnostic agent; heart failure; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; energy transfer; radiopharmaceutical agent; scintiscanning; glucose; fatty acids; oxidative stress; fluorine 18; single photon emission computer tomography; parameter; acetic acid c 11; innervation; fatty acid; management; energy metabolism; acetic acid; cerebrovascular circulation; heart; glucose transport; mitochondrion; receptor density; heart muscle; myocardium; heart muscle ischemia; acute disease; cell surface receptor; receptors, cell surface; metabolic imaging; heart muscle perfusion; catabolism; mitochondrial respiration; receptor imaging; carbon 11; muscarinic receptor; heart left ventricle function; sympathetic nervous system; coronary artery dilatation; fatty acid metabolism; congestive cardiomyopathy; heart left ventricle; adrenergic system; brain circulation; beta adrenergic receptor; iodine 123; ammonia n 13; oxygen 15; nitrogen 13; heart perfusion; heart muscle blood flow; myocardial ischemia; cardiomyopathy, dilated; humans; human; cholinergic system; idiopathic dilated cardiomyopathy; parasympathetic nervous system; 15 (4 iodophenyl) 3 methylpentadecanoic acid i 123; 4 (3 tert butylamino 2 hydroxypropoxy) 2 benzimidazolone c 11; adrenergic receptor; ephedrine c 11; epineprhine c 11; heart receptor; hydroxyephedrine c 11; palmitic acid c 11; heart muscle metabolism; heart ventricle function; receptors, adrenergic; receptors, adrenergic, beta; receptors, muscarinic
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