Hepatic artery infusion for liver metastases Journal Article
| Authors: | Kemeny, N. E.; Galsky, M. |
| Article Title: | Hepatic artery infusion for liver metastases |
| Abstract: | Hepatic metastases develop in 60% of patients with colorectal cancer and are a major cause of morbidity and mortality. While resection of hepatic metastases offers the only potential chance of cure, few patients are eligible for surgery. Furthermore, patients who undergo surgery are at high risk for recurrence. The use of hepatic arterial infusion (HAI) of chemotherapy, which is based on sound anatomic and pharmacologic principles, has been explored in an attempt to improve the outcome of patients with both unresectable and resectable liver metastases from colorectal cancer. Early trials using HAI therapy have consistently demonstrated increased response rates when compared with systemic chemotherapy. However, survival data have been difficult to interpret because both technical and methodologic problems. Concerns regarding extrahepatic progression in patients undergoing locoregional therapy have led to studies combining HAI and systemic chemotherapy. Continued research with HAI therapy will further define the optimal role of this still promising treatment modality. Copyright 2002, Elsevier Science (USA). All rights reserved. |
| Keywords: | cancer surgery; mortality; review; cancer recurrence; cancer risk; chemotherapy; colorectal cancer; morbidity; liver metastasis; hepatic artery; human |
| Journal Title: | Seminars in Colon and Rectal Surgery |
| Volume: | 13 |
| Issue: | 4 |
| ISSN: | 1043-1489 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2002-12-01 |
| Start Page: | 293 |
| End Page: | 304 |
| Language: | English |
| DOI: | 10.1053/scrs.2002.127408 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work