Neurologic complications of leukemia Journal Article

  


Authors: Demopoulos, A.; Deangelis, L. M.
Article Title: Neurologic complications of leukemia
Abstract: Purpose of review: As treatment of the leukemias improves, patients are surviving longer. Recognizing and rapidly treating metastatic complications or avoiding neurotoxic therapies improves outcome, reduces morbidity and mortality, and limits long-term sequelae. Recent findings: Neurologic dysfunction may result from leukemic infiltration of the nervous system or as a consequence of chemotherapy or prophylactic craniospinal irradiation. The present review summarizes common problems in the neurologic complications of leukemia and discusses recent advancements in their diagnosis and treatment. Summary: Topics covered in detail include central nervous system prophylaxis, leptomeningeal metastasis, and common hematologic complications affecting the brain. The findings aid in the clinical management of patients with leukemia. © 2002 Lippincott Williams & Wilkins.
Keywords: cancer chemotherapy; treatment outcome; leukemia; antibiotic agent; acute granulocytic leukemia; hydroxyurea; review; interferon; cancer radiotherapy; cytarabine; methotrexate; neurotoxicity; nuclear magnetic resonance imaging; magnetic resonance imaging; computer assisted tomography; tomography, x-ray computed; vincristine; hyperviscosity syndrome; chronic myeloid leukemia; cancer mortality; meningeal neoplasms; promyelocytic leukemia; asparaginase; cognitive defect; seizure; acute lymphocytic leukemia; tacrolimus; bone marrow transplantation; chronic lymphatic leukemia; neurological complication; granulocyte colony stimulating factor; retinoic acid; brain hemorrhage; endocrine disease; leukoencephalopathy; hematologic disease; growth retardation; fibrinogen; meningeal metastasis; procoagulant; iatrogenic disease; thrombomodulin; leptomeningeal metastasis; 5,10 methylenetetrahydrofolate reductase (fadh2); vasculitis; venous thrombosis; blood viscosity; antithrombin; protein c; disseminated intravascular coagulation; brain infection; leukemic infiltration; protein s; paraneoplastic syndromes, nervous system; cerebral sinus thrombosis; disseminated intravascular clotting; leukostasis; humans; human; neurologic complications of cancer; lipoprotein a
Journal Title: Current Opinion in Neurology
Volume: 15
Issue: 6
ISSN: 1350-7540
Publisher: Lippincott Williams & Wilkins  
Date Published: 2002-12-01
Start Page: 691
End Page: 699
Language: English
DOI: 10.1097/00019052-200212000-00006
PUBMED: 12447107
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0036907470&partnerID=40&md5=14ea37b5a29f88e010fcb5541eff5cc2
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. Lisa De Angelis
    576 De Angelis
  2. Alexis Demopoulos
    13 Demopoulos
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