A selection algorithm for internal mammary sentinel lymph node biopsy in breast cancer Journal Article
| Authors: | Bevilacqua, J. L. B.; Gucciardo, G.; Cody, H. S.; MacDonald, K. A.; Sacchini, V.; Borgen, P. I.; Van Zee, K. J. |
| Article Title: | A selection algorithm for internal mammary sentinel lymph node biopsy in breast cancer |
| Abstract: | Internal mammary lymph-node (IMN) metastases in breast carcinomas have a major influence on survival, comparable with the influence of axillary lymph-node metastases (ALNM). Prospective, randomized trials have demonstrated that complete IMN dissection as part of extended radical mastectomy does not improve overall or disease-free survival. In the subset of patients with tumours I cm or less in size and no ALNM, information on IMN status would provide important information. In these cases, the presence of IMN metastases would change the staging from stage I to stage IIIB, according to the current tumour, node and metastasis classification. More importantly, it would influence these patients' adjuvant treatment. Lymphatic mapping for sentinel lymph-node (SLN) biopsy has demonstrated extra-axillary drainage in up to 35% of patients. Recent reports have demonstrated the feasibility of internal mammary sentinel lymph-node (IM-SLN) biopsy. Here we review the general prognostic and clinical significance of tumor location and lymph-node metastases in breast cancer and discuss the specific factors associated with IMN identification, metastases and treatment in the pre-SLN and SLN eras. Based on our review, we propose an algorithm for a selective approach to IM-SLN in breast cancer. © 2002 Published by Elsevier Science Ltd. |
| Keywords: | cancer survival; controlled study; review; cancer localization; patient selection; cancer adjuvant therapy; cancer staging; lymph node metastasis; lymph node dissection; lymph nodes; lymphatic metastasis; neoplasm staging; sentinel lymph node biopsy; breast cancer; mastectomy; breast neoplasms; mammary arteries; retrospective study; algorithms; axillary lymph node; algorithm; breast carcinoma; cancer size; cancer classification; lymphatic drainage; women's health; sentinel lymph nodes; internal mammary; humans; prognosis; human; female; priority journal; axillary metastases prognosis; tumour location |
| Journal Title: | European Journal of Surgical Oncology |
| Volume: | 28 |
| Issue: | 6 |
| ISSN: | 0748-7983 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2002-09-01 |
| Start Page: | 603 |
| End Page: | 614 |
| Language: | English |
| DOI: | 10.1053/ejso.2002.1269 |
| PUBMED: | 12359195 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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