Advances in the surgical treatment of neuroblastoma: A review Journal Article
| Authors: | Murphy, J. M.; La Quaglia, M. P. |
| Article Title: | Advances in the surgical treatment of neuroblastoma: A review |
| Abstract: | Neuroblastoma prognosis varies tremendously based on the stage and biologic features of the tumor. Treatment varies depending on the risk group and can range from surgery alone for stage 1 tumors to aggressive multimodality treatment for MYCN-amplified tumors. Although surgery plays a role in the diagnosis and management of all stages of neuroblastoma, the importance of that role, especially the extent of resection, in high-risk neuroblastoma continues to evolve. In the past five years, there have been several advances in neuroblastoma surgery. Studies have demonstrated that patients with low-risk disease can be treated with surgery alone, and in a subset of patients who are neonatally diagnosed with adrenal tumors, surgery can be avoided in 80%. Recent abstracts have supported a role for >90% resection of the primary tumor in high-risk patients. This article also reviews the surgical approaches to difficult thoracic and abdominal tumors, as well as the role for minimally invasive surgery in the management of localized neuroblastoma. |
| Keywords: | cancer surgery; surgical technique; cancer staging; neurosurgery; surgical approach; risk assessment; neuroblastoma; minimally invasive surgery; thorax tumor; intraoperative radiotherapy; randomized controlled trial (topic); meta analysis (topic); phase 3 clinical trial (topic); mycn; abdominal tumor; human; article; abdominal tumors |
| Journal Title: | European Journal of Pediatric Surgery |
| Volume: | 24 |
| Issue: | 6 |
| ISSN: | 0939-7248 |
| Publisher: | Georg Thieme Verlag Kg |
| Date Published: | 2014-12-01 |
| Start Page: | 450 |
| End Page: | 456 |
| Language: | English |
| DOI: | 10.1055/s-0034-1396421 |
| PROVIDER: | scopus |
| PUBMED: | 25486413 |
| DOI/URL: | |
| Notes: | Export Date: 2 February 2015 -- Source: Scopus |
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