Swept-source optical coherence tomography features of choroidal nevi Journal Article
| Authors: | Francis, J. H.; Pang, C. E.; Abramson, D. H.; Milman, T.; Folberg, R.; Mrejen, S.; Freund, K. B. |
| Article Title: | Swept-source optical coherence tomography features of choroidal nevi |
| Abstract: | Purpose To investigate the morphologic characteristics of choroidal nevi using swept-source optical coherence tomography and compare this with enhanced-depth optical coherence tomography. Design Retrospective observational case series. Methods One choroidal nevus each from 30 eyes of 30 patients was included and received imaging with swept-source OCT (SS-OCT) and enhanced-depth imaging OCT (EDI-OCT). For SS-OCT, a scan acquisition protocol was used involving 12 mm horizontal and vertical scans in the posterior fundus. The main outcome measures were morphologic features of choroidal nevi obtained with SS-OCT imaging. These features were compared to images obtained with EDI-OCT. A 2-tailed Fisher exact test was the statistical method used. Results SS-OCT allowed for an appreciation of intralesional details: Of the 30 nevi imaged, intralesional vessels were apparent in 30 (100%), intralesional cavities in 6 (20%), intralesional granularity in 14 (47%), abnormal choriocapillaris in 25 (83%), and abnormal choriocapillaris confined to the tumor apex in 17 (58%). Distended bordering vessels were identified in 22 nevi (73%) and were significantly associated with the presence of previous or persistent subretinal fluid. Intrinsic hyperreflectivity with hyporeflective shadowing was significantly (P =.05) more apparent in 14 of 21 melanotic nevi (67%) compared with 2 of 9 amelanotic nevi (22%). Visualization of the complete nevus-scleral interface was significantly (P =.02) more apparent in 7 of 9 amelanotic nevi (78%) compared with 6 of 21 melanotic nevi (29%), and was not significantly related to tumor thickness (measured by ultrasound) or to tumor configuration. Tumor diameter (but not tumor height) was statistically significantly associated with secondary retinal changes (P =.05) and configuration (P =.01). EDI-OCT was equivalent at determining secondary retinal changes (P =.29), the presence of distended bordering vessels (P = 1), visualization of the nevus-scleral interface (P =.6), and hyporeflective gradation at the nevus-scleral interface (P =.33). However, in melanotic lesions, SS-OCT was significantly superior at visualizing intralesional vessels (P =.0002), intralesional granularity (P =.0005), and abnormal choriocapillaris (P =.0001). Conclusion Imaging of choroidal nevi with SS-OCT enables visualization of intralesional details such as vessels (present in 100% of tumors imaged), cavities, and granularity. For melanotic lesions, SS-OCT is significantly better at depicting certain intralesional characteristics compared to EDI-OCT. Distended bordering vessels were recognized in over two thirds of the nevi imaged and were significantly associated with previous or persistent subretinal fluid. |
| Keywords: | clinical article; outcome assessment; nevus; tumor volume; retrospective study; observational study; melanosis; case study; optical coherence tomography; subretinal fluid; human; male; female; priority journal; article; bruch membrane; choroid capillary layer; choroid disease; choroidal nevi; echooculography; optical coherence tomography device; swept source optical coherence tomography |
| Journal Title: | American Journal of Ophthalmology |
| Volume: | 159 |
| Issue: | 1 |
| ISSN: | 0002-9394 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2015-01-01 |
| Start Page: | 169 |
| End Page: | 176.e1 |
| Language: | English |
| DOI: | 10.1016/j.ajo.2014.10.011 |
| PROVIDER: | scopus |
| PUBMED: | 25448319 |
| DOI/URL: | |
| Notes: | Export Date: 2 February 2015 -- Source: Scopus |
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