FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma: First tolerability and feasibility results Journal Article
| Authors: | Bilger, A.; Bittner, M. I.; Grosu, A. L.; Wiedenmann, N.; Meyer, P. T.; Firat, E.; Niedermann, G.; Weber, W. A.; Milanović, D. |
| Article Title: | FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma: First tolerability and feasibility results |
| Abstract: | Background: Treatment of recurrent glioblastoma (rGBM) remains an unsolved clinical problem. Reirradiation (re-RT) can be used to treat some patients with rGBM, but as a monotherapy it has only limited efficacy. Chloroquine (CQ) is an anti-malaria and immunomodulatory drug that may inhibit autophagy and increase the radiosensitivity of GBM. Patients and methods: Between January 2012 and August 2013, we treated five patients with histologically confirmed rGBM with re-RT and 250 mg CQ daily. Results: Treatment was very well tolerated; no CQ-related toxicity was observed. At the first follow-up 2 months after finishing re-RT, two patients achieved partial response (PR), one patient stable disease (SD), and one patient progressive disease (PD). One patient with reirradiated surgical cavity did not show any sign of PD. Conclusion: In this case series, we observed encouraging responses to CQ and re-RT. We plan to conduct a CQ dose escalation study combined with re-RT. |
| Keywords: | adult; clinical article; treatment outcome; middle aged; unclassified drug; cancer recurrence; bevacizumab; cancer combination chemotherapy; cancer growth; multimodality cancer therapy; treatment duration; adjuvant therapy; cancer adjuvant therapy; cancer patient; cancer radiotherapy; radiation dose; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; follow up; multiple cycle treatment; recurrence; lomustine; irinotecan; glioblastoma; cancer size; computer assisted emission tomography; radiopharmaceutical agent; radiosensitivity; glioblastoma multiforme; drug tolerance; chloroquine; reirradiation; human; male; article; fluoro ethyl tyrosine f 18 |
| Journal Title: | Strahlentherapie und Onkologie |
| Volume: | 190 |
| Issue: | 10 |
| ISSN: | 0179-7158 |
| Publisher: | Springer Verlag |
| Date Published: | 2014-10-01 |
| Start Page: | 957 |
| End Page: | 961 |
| Language: | English |
| DOI: | 10.1007/s00066-014-0693-2 |
| PROVIDER: | scopus |
| PUBMED: | 24928248 |
| DOI/URL: | |
| Notes: | Export Date: 2 February 2015 -- Source: Scopus |
