Acinar cell cystadenoma of the pancreas: A new entity? Journal Article
| Authors: | Zamboni, G.; Terris, B.; Scarpa, A.; Kosmahl, M.; Capelli, P.; Klimstra, D. S.; Lam, P. W. Y.; Klöppel, G. |
| Article Title: | Acinar cell cystadenoma of the pancreas: A new entity? |
| Abstract: | This report describes a newly observed cystic lesion of the pancreas showing acinar cell differentiation. The patients affected by this lesion included seven women and three men (age range 16-66 years). In six patients, all of whom were female and all but one of whom suffered from abdominal pain, the cystic lesions (diameters, 4-15 cm) were detected by imaging techniques and subsequently removed. In four patients the cystic lesions were incidental findings. Eight lesions occurred as unifocal, unilocular or multilocular cysts in the head (n = 6) or tail (n = 2) of the pancreas. One lesion was bifocal (head and tail) and another involved the entire pancreas. The cysts were only rarely connected with the pancreatic duct system, but with acinar structures. Their lining cells expressed pancreatic enzymes and lacked any cellular atypia or proliferative activity (Ki67 index <1%). For a follow-up period of 6-84 months all patients remained alive and well. Although a nonneoplastic nature cannot be fully excluded, we propose that this lesion, composed of well-differentiated acinar cells, may represent the benign counterpart of the well-recognized acinar cystadenocarcinoma. We therefore suggest the term acinar cell cystadenoma. |
| Keywords: | adolescent; adult; clinical article; human tissue; protein expression; aged; middle aged; excision; clinical feature; histopathology; pancreatic neoplasms; follow up; pancreas; ki 67 antigen; cell proliferation; cell structure; diagnosis, differential; tumor volume; cystadenoma; pancreas cyst; neoplasm proteins; tumor markers, biological; cell differentiation; abdominal pain; immunoenzyme techniques; tissue distribution; antigen detection; pancreas duct; acinar cell carcinoma; radiodiagnosis; acinar cell; cystadenocarcinoma; acinar cell cystadenocarcinoma; acinar cell cystadenoma; pancreatic cystic tumors; pancreas adenoma; humans; human; male; female; article; acinar cell differentiation; acinar cystic transformation |
| Journal Title: | American Journal of Surgical Pathology |
| Volume: | 26 |
| Issue: | 6 |
| ISSN: | 0147-5185 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2002-06-01 |
| Start Page: | 698 |
| End Page: | 704 |
| Language: | English |
| DOI: | 10.1097/00000478-200206000-00002 |
| PUBMED: | 12023573 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
