Chromosomal aberrations in patients with head and neck squamous cell carcinoma do not vary based on severity of tobacco/alcohol exposure Journal Article

   

Authors:	Singh, B.; Wreesmann, V. B.; Pfister, D.; Poluri, A.; Shaha, A. R.; Kraus, D.; Shah, J. P.; Rao, P. H.
Article Title:	Chromosomal aberrations in patients with head and neck squamous cell carcinoma do not vary based on severity of tobacco/alcohol exposure
Abstract:	BACKGROUND: Head and neck squamous cell carcinomas (HNSCC) have been causally associated with tobacco and alcohol exposure. However, 10-15% of HNSCC develop in absence of significant carcinogen exposure. Several lines of evidence suggest that the genetic composition of HNSCC varies based on the extent of tobacco/alcohol exposure, however, no genome wide measures have been applied to address this issue. We used comparative genomic hybridization (CGH) to screen for the genetic aberrations in 71 patients with head and neck squamous cell carcinoma and stratified the findings by the status of tobacco/alcohol exposure. RESULTS: Although the median number of abnormalities (9), gains (6) and losses (2) per case and the overall pattern of abnormalities did not vary significantly by the extent of tobacco/alcohol exposure, individual abnormalities segregating these patients were identified. Gain of 1p (p = 0.03) and 3q amplification (p = 0.05) was significantly more common in patients with a history of tobacco/alcohol exposure. CONCLUSIONS: This data suggests that the overall accumulated chromosomal aberrations in head and neck squamous cell carcinoma are not significantly influenced by the severity of tobacco/alcohol exposure with limited exceptions.
Keywords:	adult; aged; aged, 80 and over; middle aged; genetics; squamous cell carcinoma; carcinoma, squamous cell; comparative study; metabolism; gene amplification; drug effect; chromosome aberration; head and neck neoplasms; alcohol; chromosome aberrations; nucleic acid hybridization; tobacco; chromosome deletion; head and neck tumor; ethanol; humans; human; male; female; article
Journal Title:	BMC Genetics
Volume:	3
ISSN:	1471-2156
Publisher:	Biomed Central Ltd
Date Published:	2002-11-14
Start Page:	22
Language:	English
PUBMED:	12431278
PROVIDER:	scopus
PMCID:	PMC138806
DOI:	10.1186/1471-2156-3-22
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0037079269&partnerID=40&md5=2ea2bfbf87720e2a5c3723c003c1880e
Notes:	Export Date: 14 November 2014 -- Source: Scopus

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