Malignant pancreatic tumors in childhood and adolescence: The Memorial Sloan-Kettering experience, 1967 to present Journal Article

  


Authors: Shorter, N. A.; Glick, R. D.; Klimstra, D. S.; Brennan, M. F.; LaQuaglia, M. P.
Article Title: Malignant pancreatic tumors in childhood and adolescence: The Memorial Sloan-Kettering experience, 1967 to present
Abstract: Background: Malignant tumors of the pancreas are uncommon in children and adolescents and only recently have the most common tumor types been well characterized. As a result, the treatment approach to these patients has yet to be standardized, and much of the information available in the literature, particularly with regard to the role of chemotherapy and radiation, is anecdotal. Methods: A retrospective review was undertaken of all patients less than 21 years of age with malignant pancreatic tumors who were cared for at Memorial Sloan-Kettering since 1967. Results: Seventeen patients were identified. The pathologic types were pancreatoblastoma, 5; solid pseudopapillary tumor, 7; acinar cell carcinoma, 1; nonfunctioning pancreatic endocrine neoplasm, 1; malignant VIPoma, 1; and PNET, 2. A complete resection of the primary tumor was achieved in 82%, and 12 of 15 are alive, 10 with no evidence of disease. Chemotherapy or radiation were used in selected cases. Conclusions: Unlike malignant pancreatic tumors in adults, tumors in children and adolescents usually are resectable, and long-term survival is likely. However, the risk of recurrence for pancreatoblastoma is high. The roles of chemotherapy and radiation remain undefined. Copyright 2002, Elsevier Science (USA). All rights reserved.
Keywords: adolescent; adult; cancer chemotherapy; child; clinical article; controlled study; preschool child; treatment outcome; child, preschool; disease-free survival; retrospective studies; multimodality cancer therapy; liver neoplasms; adjuvant therapy; cancer radiotherapy; disease free survival; pancreas resection; chemotherapy, adjuvant; combined modality therapy; pancreatic neoplasms; radiotherapy, adjuvant; antineoplastic agent; pancreas; metastasis; neoplasm recurrence, local; lung neoplasms; pathology; retrospective study; childhood cancer; risk assessment; lung tumor; tumors; tumor recurrence; adjuvant chemotherapy; liver tumor; pancreas tumor; pancreatectomy; acinar cell carcinoma; carcinoma, acinar cell; endocrine tumor; vipoma; blastoma; humans; human; male; female; priority journal; article
Journal Title: Journal of Pediatric Surgery
Volume: 37
Issue: 6
ISSN: 0022-3468
Publisher: W.B. Saunders Co-Elsevier Inc.  
Date Published: 2002-01-01
Start Page: 887
End Page: 892
Language: English
DOI: 10.1053/jpsu.2002.32897
PUBMED: 12037756
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0035987707&partnerID=40&md5=8698a22ae166a83543723e1d32a2904e
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    1059 Brennan
  2. Michael P La Quaglia
    411 La Quaglia
  3. Nicholas A Shorter
    5 Shorter
  4. Richard D Glick
    10 Glick
  5. David S Klimstra
    978 Klimstra
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