Lack of effect of a low-fat, high-fruit, -vegetable, and -fiber diet on serum prostate-specific antigen of men without prostate cancer: Results from a randomized trial Journal Article

  

Authors:	Shike, M.; Latkany, L.; Riedel, E.; Fleisher, M.; Schatzkin, A.; Lanza, E.; Corle, D.; Begg, C. B.
Article Title:	Lack of effect of a low-fat, high-fruit, -vegetable, and -fiber diet on serum prostate-specific antigen of men without prostate cancer: Results from a randomized trial
Abstract:	Purpose: To determine whether a diet low in fat and high in fruits, vegetables, and fiber may be protective against prostate cancer by having an impact on serial levels of serum prostate-specific antigen (PSA). Methods: Six hundred eighty-nine men were randomized to the intervention arm and 661 to the control arm. The intervention group received intensive counseling to consume a diet low in fat and high in fiber, fruits, and vegetables. The control group received a standard brochure on a healthy diet. PSA in serum was measured at baseline and annually thereafter for 4 years, and newly diagnosed prostate cancers were recorded. Results: The individual PSA slope for each participant was calculated, and the distributions of slopes were compared between the two groups. There was no significant difference in distributions of the slopes (P = .99). The two groups were identical in the proportions of participants with elevated PSA at each time point. There was no difference in the PSA slopes between the two groups (P = .34) and in the frequencies of elevated PSA values for those with elevated PSA at baseline. Incidence of prostate cancer during the 4 years was similar in the two groups (19 and 22 in the control and intervention arms, respectively). Conclusion: Dietary intervention over a 4-year period with reduced fat and increased consumption of fruits, vegetables, and fiber has no impact on serum PSA levels in men. The study also offers no evidence that this dietary intervention over a 4-year period affects the incidence of prostate cancer during the 4 years. © 2002 by American Society of Clinical Oncology.
Keywords:	adult; controlled study; middle aged; major clinical study; clinical trial; prostate specific antigen; protein blood level; cancer prevention; controlled clinical trial; randomized controlled trial; food habits; risk; prostate cancer; prostate-specific antigen; prostatic neoplasms; antigen detection; health promotion; fruit; vegetable; vegetables; diet therapy; regression analysis; statistics, nonparametric; low fat diet; high fiber diet; diet, fat-restricted; dietary fiber; humans; human; male; priority journal; article
Journal Title:	Journal of Clinical Oncology
Volume:	20
Issue:	17
ISSN:	0732-183X
Publisher:	American Society of Clinical Oncology
Date Published:	2002-09-01
Start Page:	3592
End Page:	3598
Language:	English
DOI:	10.1200/jco.2002.02.040
PUBMED:	12202659
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0036727173&partnerID=40&md5=1a8d20fa07f85ffae2e02876efa536f7
Notes:	Export Date: 14 November 2014 -- Source: Scopus

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