Synthesis and biological activity of AHMA-EDTA conjugates Journal Article

  


Authors: Rastogi, K.; Chou, T. C.; Ting, C. Y.; Chen, K. T.; Hwang, J.; Su, T. L.
Article Title: Synthesis and biological activity of AHMA-EDTA conjugates
Abstract: Three types of 9-anilinoacridine-EDTA (AHMA-EDTA) conjugates in which the amino group of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, an potential DNA-topoisomerase II-mediated anticancer agent) has been linked to EDTA either directly (AHMA-EDTA) or with a short hydrocarbon tether such as glycine (AHMA-Gly-EDTA) and γ-amino butyric acid (AHMA-GABA-EDTA) were synthesized for evaluation of their antitumor and DNA cleavage activities.
Keywords: controlled study; unclassified drug; human cell; antineoplastic activity; drug potency; drug design; drug synthesis; structure activity relation; tumor cell line; bleomycin; 9 anilinoacridine derivative; drug cytotoxicity; lymphatic leukemia; dna topoisomerase (atp hydrolysing); drug binding; drug conjugation; glycine; dna cleavage; intercalation complex; 4 aminobutyric acid; edetic acid; melting point; human; article; 3 (9 acridinylamino) 5 hydroxymethylaniline derivative
Journal Title: Medicinal Chemistry Research
Volume: 11
Issue: 5
ISSN: 1054-2523
Publisher: Birkhauser Boston Inc  
Date Published: 2002-01-01
Start Page: 278
End Page: 292
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0036976317&partnerID=40&md5=2fc1c3361a4e0eb7aca9b55e776c7cdc
Notes: Export Date: 14 November 2014 -- Source: Scopus