A phase II trial of bryostatin-1 in patients with metastatic or recurrent squamous cell carcinoma of the head and neck Journal Article
| Authors: | Pfister, D. G.; McCaffrey, J.; Zahalsky, A. J.; Schwartz, G. K.; Lis, E.; Gerald, W.; Huvos, A.; Shah, J.; Kraus, D.; Shaha, A.; Singh, B.; Wolden, S.; Zelefsky, M.; Palgi, I. |
| Article Title: | A phase II trial of bryostatin-1 in patients with metastatic or recurrent squamous cell carcinoma of the head and neck |
| Abstract: | Bryostatin-1 is a macrocyclic lactone that has been shown to modulate Protein Kinase C activity and has demonstrated antitumor activity in vitro and in vivo. Fifteen patients with metastatic or recurrent squamous cell carcinoma of the head and neck were treated with bryostatin-1 at a dose of 25 mcg/m2 by continuous intravenous infusion over 24 hours once weekly for three weeks followed by a break week to complete a four-week cycle. There were no major objective responses in the 14 evaluable patients. One patient with nasopharynx cancer had disease stabilization for 4 months prior to being removed from the study due to medical issues. This clinical benefit corresponded to a radiographic decrease in metabolic activity on positron emission tomograpy (PET) scan as well as molecular evidence of tumor apoptosis in a poly[ADP-ribose] polymerase (PARP) cleavage assay. Bryostatin-1 is not recommended for use as a single agent for the treatment of squamous cell head and neck cancer. Further investigation is warranted to determine the strength of the correlation between bryostatin-1 activity and PARP cleavage as a surrogate molecular marker of apoptosis. |
| Keywords: | adult; clinical article; aged; middle aged; clinical trial; squamous cell carcinoma; carcinoma, squamous cell; antineoplastic agents; positron emission tomography; recurrent cancer; metastasis; apoptosis; phase 2 clinical trial; neoplasm recurrence, local; gastrointestinal symptom; antineoplastic activity; enzyme activity; head and neck cancer; head and neck neoplasms; protein kinase c; nasopharynx cancer; bryostatin 1; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; infusions, intravenous; head and neck carcinoma; lactones; macrolides; bryostatin-1; humans; human; male; female; priority journal; article |
| Journal Title: | Investigational New Drugs |
| Volume: | 20 |
| Issue: | 1 |
| ISSN: | 0167-6997 |
| Publisher: | Springer |
| Date Published: | 2002-02-01 |
| Start Page: | 123 |
| End Page: | 127 |
| Language: | English |
| DOI: | 10.1023/a:1014449309165 |
| PUBMED: | 12003188 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
