Strategies to overcome immune ignorance and tolerance Journal Article


Authors: Perales, M. A.; Blachere, N. E.; Engelhorn, M. E.; Ferrone, C. R.; Gold, J. S.; Gregor, P. D.; Noffz, G.; Wolchok, J. D.; Houghton, A. N.
Article Title: Strategies to overcome immune ignorance and tolerance
Abstract: Cancer poses a difficult problem for immunotherapy because it arises from the host's own tissues. Many of the target antigens are tissue-specific molecules shared by cancer cells and normal cells. Thus, these are weak antigens that do not typically elicit immunity. In addition, tumors have several features that make their recognition and destruction by the immune system difficult. Despite these obstacles, several strategies for developing effective tumor immunity have been developed. Crucial to these approaches is the discovery and understanding of the molecular identity of antigens and the mechanisms involved in tumor immunity. In this review, strategies to overcome immune ignorance and tolerance are discussed. © 2002 Academic Press.
Keywords: signal transduction; gene mutation; nonhuman; neoplasms; cancer immunotherapy; melanoma; immune system; tumor differentiation; gene product; cell differentiation; tumor antigen; immunological tolerance; immune tolerance; immune response; antigens, neoplasm; cancer cell; epitope; tumor immunity; virus antigen; tolerance; differentiation antigen; molecular stability; cancer; humans; human; article
Journal Title: Seminars in Cancer Biology
Volume: 12
Issue: 1
ISSN: 1044-579X
Publisher: Academic Press Inc., Elsevier Science  
Date Published: 2002-02-01
Start Page: 63
End Page: 71
Language: English
DOI: 10.1006/scbi.2001.0397
PUBMED: 11926414
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. Cristina Ferrone
    32 Ferrone
  2. Polly Gregor
    29 Gregor
  3. Jedd D Wolchok
    830 Wolchok
  4. Jason Gold
    21 Gold
  5. Gabriele Noffz
    4 Noffz
  6. Miguel-Angel Perales
    602 Perales
  7. Alan N Houghton
    343 Houghton
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