Transmission of olfactory information between three populations of neurons in the antennal lobe of the fly Journal Article

  

Authors:	Ng, M.; Roorda, R. D.; Lima, S.; Zemelman, B. V.; Morcillo, P.; Miesenboeck, G.
Article Title:	Transmission of olfactory information between three populations of neurons in the antennal lobe of the fly
Abstract:	Three classes of neurons form synapses in the antennal lobe of Drosophila, the insect counterpart of the vertebrate olfactory bulb: olfactory receptor neurons, projection neurons, and inhibitory local interneurons. We have targeted a genetically encoded optical reporter of synaptic transmission to each of these classes of neurons and visualized population responses to natural odors. The activation of an odor-specific ensemble of olfactory receptor neurons leads to the activation of a symmetric ensemble of projection neurons across the glomerular synaptic relay. Virtually all excited glomeruli receive inhibitory input from local interneurons. The extent, odor specificity, and partly interglomerular origin of this input suggest that inhibitory circuits assemble combinatorially during odor presentations. These circuits may serve as dynamic templates that extract higher order features from afferent activity patterns.
Keywords:	immunohistochemistry; signal transduction; controlled study; nonhuman; animal cell; animals; animal tissue; odor; nerve tissue proteins; drosophila; neurons; cell population; models, animal; gene expression regulation, developmental; recombinant fusion proteins; interneuron; drosophila melanogaster; drosophila proteins; genetic markers; sensory nerve cell; olfactory bulb; nerve net; synapses; synapse; synaptic transmission; olfactory receptor; antenna; olfactory pathways; male; female; priority journal; article; ganglia, invertebrate; odors; smell
Journal Title:	Neuron
Volume:	36
Issue:	3
ISSN:	0896-6273
Publisher:	Cell Press
Date Published:	2002-10-24
Start Page:	463
End Page:	474
Language:	English
DOI:	10.1016/s0896-6273(02)00975-3
PUBMED:	12408848
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0037168107&partnerID=40&md5=e7cb918317c078b9bafedaa961c17378
Notes:	Export Date: 14 November 2014 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/66815