Fatal respiratory failure associated with treatment of prostate cancer using docetaxel and estramustine Journal Article


Authors: Morris, M. J.; Santamauro, J.; Shia, J.; Schwartz, L.; Vander Els, N.; Kelly, K.; Scher, H.
Article Title: Fatal respiratory failure associated with treatment of prostate cancer using docetaxel and estramustine
Abstract: Chemotherapy that targets microtubular trafficking induces responses in most patients with prostate cancer. One regimen under investigation is the combination of docetaxel and estramustine. We report on 2 patients with androgen-independent disease who received continuous weekly docetaxel and estramustine and who died of irreversible respiratory failure. The clinical, pathologic, and radiographic data support drug toxicity as the likely etiology. Inclusive of these patients, only 17 cases (10 fatal) of acute pulmonary toxicity using docetaxel have been reported, despite its wide use. We recommend that patients receiving weekly docetaxel, with or without estramustine, have frequent treatment breaks and be evaluated with computed tomography of the chest every 8 weeks. © 2002, Elsevier Science Inc.
Keywords: controlled study; human tissue; aged; clinical feature; disease course; case report; cancer combination chemotherapy; paclitaxel; antineoplastic agent; computer assisted tomography; lung toxicity; antineoplastic combined chemotherapy protocols; docetaxel; prostatic neoplasms; drug fatality; taxoids; fatal outcome; prostate carcinoma; respiratory insufficiency; respiratory failure; estramustine; lung examination; humans; human; male; priority journal; article
Journal Title: Urology
Volume: 60
Issue: 6
ISSN: 0090-4295
Publisher: Elsevier Science, Inc.  
Date Published: 2002-12-01
Start Page: 1111vi
End Page: 1111ix
Language: English
PUBMED: 12475686
PROVIDER: scopus
DOI: 10.1016/S0090-4295(02)01921-0
DOI/URL:
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. Michael Morris
    252 Morris
  2. Lawrence H Schwartz
    271 Schwartz
  3. Jinru Shia
    436 Shia
  4. Howard Scher
    738 Scher