Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice Journal Article
| Authors: | Kogan, S. C.; Ward, J. M.; Anver, M. R.; Berman, J. J.; Brayton, C.; Cardiff, R. D.; Carter, J. S.; De Coronado, S.; Downing, J. R.; Fredrickson, T. N.; Haines, D. C.; Harris, A. W.; Harris, N. L.; Hiai, H.; Jaffe, E. S.; MacLennan, I. C. M.; Pandolfi, P. P.; Pattengale, P. K.; Perkins, A. S.; Simpson, R. M.; Tuttle, M. S.; Wong, J. F.; Morse, H. C. 3rd |
| Article Title: | Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice |
| Abstract: | The hematopathology subcommittee of the Mouse Models of Human Cancers Consortium recognized the need for a classification of murine hematopoietic neoplasms that would allow investigators to diagnose lesions as well-defined entities according to accepted criteria. Pathologists and investigators worked cooperatively to develop proposals for the classification of lymphoid and nonlymphoid hematopoietic neoplasms. It is proposed here that nonlymphoid hematopoietic neoplasms of mice be classified in 4 broad categories: nonlymphoid leukemias, nonlymphoid hematopoietic sarcomas, myeloid dysplasias, and myeloid proliferations (nonreactive). Criteria for diagnosis and subclassification of these lesions include peripheral blood findings, cytologic features of hematopoietic tissues, histopathology, immunophenotyping, genetic features, and clinical course. Differences between murine and human lesions are reflected in the terminology and methods used for classification. This classification will be of particular value to investigators seeking to develop, use, and communicate about mouse models of human hematopoietic neoplasms. © 2002 by The American Society of Hematology. |
| Keywords: | controlled study; myeloproliferative disorders; leukemia; histopathology; nonhuman; united states; mouse; animals; mice; animal experiment; animal model; transplantation; sarcoma; blood disease; hematologic neoplasms; immunophenotyping; tumor classification; national institutes of health (u.s.); granulocytic sarcoma; myeloid leukemia; myelodysplasia; neural tube defects; acute megakaryocytic leukemia; humans; priority journal; article; nonlymphatic leukemia |
| Journal Title: | Blood |
| Volume: | 100 |
| Issue: | 1 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2002-07-01 |
| Start Page: | 238 |
| End Page: | 245 |
| Language: | English |
| DOI: | 10.1182/blood.V100.1.238 |
| PUBMED: | 12070033 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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