Urine antibody against human cancer antigen NY-ESO-1 Journal Article
| Authors: | Jäger, D.; Stockert, E.; Karbach, J.; Herrlinger, K.; Atmaca, A.; Arand, M.; Chen, Y. T.; Gnjatic, S.; Old, L. J.; Knuth, A.; Jäger, E. |
| Article Title: | Urine antibody against human cancer antigen NY-ESO-1 |
| Abstract: | NY-ESO-1 is one of the most immunogenic tumor antigens known to date. Spontaneous humoral and cellular immune responses against NY-ESO-1 are detected in a substantial proportion of patients with NY-ESO-1 positive cancers. NY-ESO-1 serum antibody is dependent on the presence of NY-ESO-1+ cancer cells, and antibody titers correlate with the clinical development of the disease. NY-ESO-1 serum antibody is associated with detectable NY-ESO-1-specific CD8+ T cell reactivity. High titers of NY-ESO-1 serum antibodies are found in patients with advanced NY-ESO-1+ malignancies. Urine samples of seropositive patients with normal kidney function were tested for NY-ESO-1 antibody by Western blotting and enzyme-linked immunosorbent assay (ELISA). Antibodies to NY-ESO-1 were found in the urine of patients whose NY-ESO-1 serum antibody titers were 1:10,000 or higher by Western blotting. In patients with weak (positive at 1:250, negative at 1:1,000) or no reactivity, urine antibody was not detectable. No urine NY-ESO-1 antibody was found in patients without detectable NY-ESO-1 serum antibody. Our results show that urine analysis for NY-ESO-1 antibody identifies patients with strong NY-ESO-1 immunity. Urine antibody detection may also be of value in the monitoring of spontaneous and vaccine-induced immunity against other defined tumor antigens. |
| Keywords: | clinical article; controlled study; unclassified drug; human cell; disease association; patient monitoring; tumor antigen; enzyme linked immunosorbent assay; ny eso 1 antigen; western blotting; urine; urinalysis; elisa; antibody detection; t lymphocyte subpopulation; antibody titer; cancer antibody; ny-eso-1; ny eso 1 antibody; cancer; human; article; tumor antibodies |
| Journal Title: | Cancer Immunity |
| Volume: | 2 |
| ISSN: | 1424-9634 |
| Publisher: | Academy of Cancer Immunology |
| Date Published: | 2002-08-06 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 12747755 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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