Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors Journal Article

Authors: Holen, K. D.; Klimstra, D. S.; Hummer, A.; Gonen, M.; Conlon, K.; Brennan, M.; Saltz, L. B.
Article Title: Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors
Abstract: Purpose: Acinar cell carcinoma is a rare tumor of the exocrine pancreas. Clinical features such as prognostic information, survival, and treatment outcomes are unknown. We present the largest retrospective review to date. Patients and Methods: Thirty-nine patients with pathologically confirmed acinar neoplasms of the pancreas were identified between August 1981 and January 2001. Demographic data, tumor characteristics, and treatment information were obtained by chart review. Survival probabilities were estimated by using the Kaplan-Meier method and compared using the log-rank test. Results: The median survival for all patients was 19 months. On the basis of a univariate analysis, the patients' stage of disease correlated significantly with survival. The median survival of patients with localized disease was 38 months, versus 14 months for those presenting with metastases (P = 0.03). Patients who could be treated with surgery as first-line therapy had a longer survival time (36 months) compared with those who did not have surgery (14 months). Two of 18 patients who received chemotherapy and three of eight patients who received radiation had a major response. Conclusion: The survival curves suggest a more aggressive cancer than pancreatic endocrine neoplasms but one that is less aggressive than ductal adenocarcinoma of the pancreas. Those patients who present with localized disease have a much better prognosis than those who present with metastases. There is a high recurrence rate after complete surgical resection, suggesting that micrometastases are present even in localized disease and that adjuvant therapies may be indicated. Chemotherapy and radiation afford disappointing results, however, and novel therapies are needed. © 2002 by American Society of Clinical Oncology.
Keywords: adolescent; adult; cancer chemotherapy; cancer survival; clinical article; controlled study; human tissue; treatment outcome; aged; middle aged; cancer surgery; survival rate; retrospective studies; clinical feature; cancer localization; cancer recurrence; treatment planning; cancer radiotherapy; combined modality therapy; pancreatic neoplasms; antineoplastic agent; neoplasm staging; metastasis; abdominal pain; pancreas carcinoma; pancreas duct; neoplasm metastasis; pancreas adenocarcinoma; acinar cell carcinoma; carcinoma, acinar cell; humans; prognosis; human; male; female; priority journal; article
Journal Title: Journal of Clinical Oncology
Volume: 20
Issue: 24
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2002-12-15
Start Page: 4673
End Page: 4678
Language: English
DOI: 10.1200/jco.2002.02.005
PUBMED: 12488412
PROVIDER: scopus
Notes: Export Date: 14 November 2014 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Amanda J Hummer
    60 Hummer
  2. Murray F Brennan
    761 Brennan
  3. Leonard B Saltz
    580 Saltz
  4. Mithat Gonen
    701 Gonen
  5. Kyle D Holen
    4 Holen
  6. Kevin C Conlon
    112 Conlon
  7. David S Klimstra
    844 Klimstra